Lhasa Literature Review

Pharmacological Research: Vol 57, Issue 3

2008-04-28T16:08:00.000+01:00

Pharmacology and Therapeutics: Vol 118, Issue 1

2008-04-28T16:04:00.000+01:00

European Journal of Pharmacology: Vol 585, Issues 2-3

2008-04-28T15:59:00.000+01:00

European Journal of Pharmaceutical Sciences: Vol 34, Issue 1

2008-04-28T15:56:00.000+01:00

Toxicology Letters: Vol 178, Issue 2

2008-04-28T10:36:00.000+01:00

1.
Editorial Board Page CO2

2.
Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: Involvement of PARP-1 and p53 proteins Pages 71-76 Antonietta Santoro, Giuseppe Bianco, Patrizia Picerno, Rita Patrizia Aquino, Giuseppina Autore, Stefania Marzocco, Patrizia Gazzerro, Maria Brigida Lioi and Maurizio Bifulco

3.
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine Pages 77-82 Qingsu Xia, Jian Yan, Ming W. Chou and Peter P. Fu

4.
Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse Pages 83-87 James J. Pestka, Zahidul Islam and Chidozie J. Amuzie

5.
Polymorphisms and haplotypes of DNA repair and xenobiotic metabolism genes and risk of DNA damage in Chinese vinyl chloride monomer (VCM)-exposed workers Pages 88-94 Shou-Min Zhu, Zhao-Lin Xia, Ai-Hong Wang, Xue-Feng Ren, Jie Jiao, Nai-Qing Zhao, Ji Qian, Li Jin and David C. Christiani

6.
Non-functionalized multi-walled carbon nanotubes alter the paracellular permeability of human airway epithelial cells Pages 95-102 Bianca Maria Rotoli, Ovidio Bussolati, Massimiliano G. Bianchi, Amelia Barilli, Chidambara Balasubramanian, Stefano Bellucci and Enrico Bergamaschi

7.
Steroid secretion following exposure of ovarian follicular cells to single congeners and defined mixture of polybrominateddibenzoethers (PBDEs), p,p′-DDT and its metabolite p,p′-DDE Pages 103-109 Ewa Ł. Gregoraszczuk, Agnieszka Rak, K. Kawalec and Erik Ropstad

8.
Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats Pages 110-116 Wan-Seob Cho, Beom Seok Han, Byeongwoo Ahn, Ki Taek Nam, Mina Choi, Sang Yeon Oh, Seung Hee Kim, Jayoung Jeong and Dong Deuk Jang

9.
Significant decreasing trend in human dietary exposure to PCDD/PCDFs and PCBs in Catalonia, Spain Pages 117-126 Juan M. Llobet, Roser Martí-Cid, Victoria Castell and José L. Domingo

10.
Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways Pages 127-130 M.T. Kleinman, J.A. Araujo, A. Nel, C. Sioutas, A. Campbell, P.Q. Cong, H. Li and S.C. Bondy

11.
Inhalation and epidermal exposure of volunteers to ethylene glycol: Kinetics of absorption, urinary excretion, and metabolism to glycolate and oxalate Pages 131-141 Swapna Upadhyay, Joern Carstens, Dominik Klein, Thomas H. Faller, Stephan Halbach, Werner Kirchinger, Winfried Kessler, György A. Csanády and Johannes G. Filser

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis: Vol 641, Issues 1-2

2008-04-28T10:33:00.000+01:00

Research papers

2.
Impact of estrogenic compounds on DNA integrity in human spermatozoa: Evidence for cross-linking and redox cycling activities Pages 1-11 L.E. Bennetts, G.N. De Iuliis, B. Nixon, M. Kime, K. Zelski, C.M. McVicar, S.E. Lewis and R.J. Aitken

3.
Haplotypes of nine single nucleotide polymorphisms on chromosome 19q13.2-3 associated with susceptibility of lung cancer in a Chinese population Pages 12-18 Jiaoyang Yin, Ulla Vogel, Yegang Ma, Rong Qi and Huiwen Wang

4.
Translesion synthesis of 7,8-dihydro-8-oxo-2′-deoxyguanosine by DNA polymerase eta in vivo Pages 19-26 Dong-Hyun Lee and Gerd P. Pfeifer

5.
Large-scale analysis of the genetic and epigenetic alterations in hepatocellular carcinoma from Southeast China Pages 27-35 Hang Su, Jing Zhao, Yujuan Xiong, Teng Xu, Fan Zhou, Yunfei Yuan, Ying Zhang and Shi-Mei Zhuang

6.
Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes Pages 36-42 Ludovit Musak, Pavel Soucek, Ludmila Vodickova, Alessio Naccarati, Erika Halasova, Veronika Polakova, Jana Slyskova, Simona Susova, Janka Buchancova, Zdenek Smerhovsky, Jana Sedikova, Gabriela Klimentova, Oto Osina, Kari Hemminki and Pavel Vodicka

7.
Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone Pages 43-47 Daniel J. Smart, H. Dorota Halicka, Gabriele Schmuck, Frank Traganos, Zbigniew Darzynkiewicz and Gary M. Williams

Short communications

8.
Involvement of recQ in the ultraviolet damage repair pathway in Deinococcus radiodurans Pages 48-53 Xiaoting Hua, Lifen Huang, Bing Tian and Yuejin Hua

9.
Diesel exhaust particles are mutagenic in FE1-Muta™Mouse lung epithelial cells Pages 54-57 Nicklas Raun Jacobsen, Peter Møller, Corey Alexander Cohn, Steffen Loft, Ulla Vogel and Håkan Wallin

10.
Stage-specificity of spontaneous mutation at a tandem repeat DNA locus in the mouse germline Pages 58-60 Morag Shanks, Lydia Riou, Pierre Fouchet and Yuri E. Dubrova

Letter to the Editor

11.
No somatic mutations detected in the Mad2 gene in 658 human tumors Pages 61-63 D.A. Ruddy, B. Gorbatcheva, G. Yarbrough, R. Schlegel and J.E. Monahan

12.
Contents List Page III

DNA Repair: Vol 7, Issue 5,

2008-04-28T10:27:00.000+01:00

This month in DNA Repair

1.
This Month in DNA Repair Page 683

Letter to the Editor

2.
Rearrangements in the flanking sequences of the triplet repeat of the FMR1 gene give clues to the mechanisms involved in repeat instability in fragile X Pages 684-685 Tarja Mononen, Harriet von Koskull, Raija-Liisa Airaksinen and Vesa Juvonen

Mini review

3.
The consequences of Rad51 overexpression for normal and tumor cells Pages 686-693 Hannah L. Klein

Research papers

4.
Tissue-specific differences in the accumulation of sequence rearrangements with age Pages 694-703 Dominika M. Wiktor-Brown, Werner Olipitz, Carrie A. Hendricks, Rebecca E. Rugo and Bevin P. Engelward

5.
Differential repair of UVB-induced cyclobutane pyrimidine dimers in cultured human skin cells and whole human skin Pages 704-712 Stéphane Mouret, Marie Charveron, Alain Favier, Jean Cadet and Thierry Douki

6.
Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line Pages 713-724 Virginie Faure, Thomas Wenner, Carol Cooley, Emer Bourke, Christine J. Farr, Shunichi Takeda and Ciaran G. Morrison

7.
The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation Pages 725-733 Hongyan Wang, Xiang Wang, Piyan Zhang and Ya Wang

8.
Functionally distinct nucleosome-free regions in yeast require Rad7 and Rad16 for nucleotide excision repair Pages 734-743 Teresa Lettieri, Rolf Kraehenbuehl, Christoph Capiaghi, Magdalena Livingstone-Zatchej and Fritz Thoma

9.
Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy Pages 744-750 Wim J. Kleijer, Vincent Laugel, Mark Berneburg, Tiziana Nardo, Heather Fawcett, Alexei Gratchev, Nicolaas G.J. Jaspers, Alain Sarasin, Miria Stefanini and Alan R. Lehmann

10.
Direct involvement of the tumor suppressor p53 in nucleotide excision repair Pages 751-761 Yu-Ching Chang, Kun-Yan Jan, Chun-An Cheng, Chu-Bin Liao and Yin-Chang Liu

11.
Mutations to Ku reveal differences in human somatic cell lines Pages 762-774 Kazi R. Fattah, Brian L. Ruis and Eric A. Hendrickson

12.
PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage Pages 775-787 Thomas Göhler, Ivan M. Munoz, John Rouse and J. Julian Blow

13.
RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae Pages 788-800 Nicholas R. Pannunzio, Glenn M. Manthey and Adam M. Bailis

14.
Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae Pages 801-810 Ewa T. Lis, Bryan M. O’Neill, Cristina Gil-Lamaignere, Jodie K. Chin and Floyd E. Romesberg

Brief report

15.
Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage Pages 811-818 Eris Duro, Jessica A. Vaisica, Grant W. Brown and John Rouse

Hot topics in DNA Repair

16.
DNA repair gets physical: Mapping an XPA-binding site on ERCC1 Pages 819-826 Deborah L. Croteau, Ye Peng and Bennett Van Houten

Book review

17.
P.U. Giacomoni, Editor, Biophysical and Physiological Effects of Solar Radiation on Human Skin, Royal Society of Chemistry, Cambridge, UK (2007) ISBN-10: 08540289X; ISBN-13: 978-0854042890. Pages 827-828 James E. Cleaver

18.
Contents List Page III

Biochemical Pharmacology: Vol 75, Issue 10

2008-04-28T10:23:00.000+01:00

Commentary

2.
Uracil nucleotides: From metabolic intermediates to neuroprotection and neuroinflammation Pages 1869-1881 Davide Lecca and Stefania Ceruti

3.
The apelin–APJ system in heart failure: Pathophysiologic relevance and therapeutic potential Pages 1882-1892 Alan G. Japp and David E. Newby

4.
New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets Pages 1893-1900 Andrea Huwiler and Josef Pfeilschifter

Antibiotics and Chemotherapeutics

5.
Cytotoxic activities of nucleoside and nucleobase analog drugs in malignant mesothelioma: Characterization of a novel nucleobase transport activity Pages 1901-1911 Deepti Damaraju, Vijaya L. Damaraju, Miranda Brun, Delores Mowles, Michelle Kuzma, Richard C. Berendt, Michael B. Sawyer and Carol E. Cass

6.
Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines Pages 1912-1923 Adrián M. Ramos and Patricio Aller

7.
Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1 Pages 1924-1934 Anand Krishnan, Ramkumar Hariharan, S. Asha Nair and M. Radhakrishna Pillai

8.
Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: Role of reactive oxygen species production and glutathione depletion Pages 1935-1945 Conrad Ortiz, Laia Caja, Patricia Sancho, Esther Bertran and Isabel Fabregat

9.
Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway Pages 1946-1958 Young-Ho Kim, Dae-Hee Lee, Jae-Hoon Jeong, Zong Sheng Guo and Yong J. Lee

10.
Synthesis of bisphosphonate derivatives of ATP by T4 DNA ligase, ubiquitin activating enzyme (E1) and other ligases Pages 1959-1965 María A. Günther Sillero, Anabel de Diego, Francisco J. Pérez-Zúñiga and Antonio Sillero

Cardiovascular Pharmacology

11.
Diadenosine polyphosphates Ap3A and Ap4A, but not Ap5A or Ap6A, induce proliferation of vascular smooth muscle cells Pages 1966-1973 Peter Bobbert, Hartmut Schlüter, Heinz Peter Schultheiss and Hans Peter Reusch

Inflammation and Immunopharmacology

12.
Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp Pages 1974-1980 Naoto Kamio, Hideki Hashizume, Sumi Nakao, Kiyoshi Matsushima and Hiroshi Sugiya

Metabolic Disorders and Endocrinology

13.
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR Pages 1981-1993 Ying Cai, Qidi Wang, Zhidong Ling, Daniel Pipeleers, Paul McDermott, Mario Pende, Harry Heimberg and Mark Van de Casteele

Neuropharmacology

14.
Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism Pages 1994-2006 Pamela Maher

15.
Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors Pages 2007-2019 Valérie Audinot, Anne Bonnaud, Line Grandcolas, Marianne Rodriguez, Nadine Nagel, Jean-Pierre Galizzi, Ales Balik, Sophie Messager, David G. Hazlerigg, Perry Barrett, Philippe Delagrange and Jean A. Boutin

Pharmacokinetics and Drug Metabolism

16.
Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells Pages 2020-2033 Dae-Hee Lee, Clifford Kim, Lin Zhang and Yong J. Lee

Toxicology

17.
Benzo[a]pyrene inhibits osteoclastogenesis by affecting RANKL-induced activation of NF-κB Pages 2034-2044 I. Voronov, K. Li, H.C. Tenenbaum and M.F. Manolson

18.
Reactions of isodimethoate with human red cell acetylcholinesterase Pages 2045-2053 Peter Eyer, Maria Radtke and Franz Worek

Bioorganic and Medicinal Chemistry: Vol 16, Issue 8

2008-04-28T10:20:00.000+01:00

2.
Graphical contents list Pages 4189-4202

REVIEW

3.
Tetramic and tetronic acids: An update on new derivatives and biological aspects Pages 4203-4221 Rainer Schobert and Andrea Schlenk

ARTICLES

4.
Synthesis of 1-substituted 3-pyridinylmethylidenylindolin-2-ones and 1-substituted 3-quinolinylmethylidenylindolin-2-ones as the enhancers of ATRA-induced differentiation in HL-60 cells Pages 4222-4232 Chi-Ying Hung, Mei-Hua Hsu, Li-Jiau Huang, Chrong-Shiong Hwang, On Lee, Chen-Yi Wu, Chih-Hung Chen and Sheng-Chu Kuo

5.
Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid Pages 4233-4241 Jared Kuemmerle, Songchun Jiang, Ben Tseng, Shailaja Kasibhatla, John Drewe and Sui Xiong Cai

6.
Formation of fluorine-18 labeled diaryl ureas—labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis Pages 4242-4251 O. Ilovich, O. Jacobson, Y. Aviv, A. Litchi, R. Chisin and E. Mishani

7.
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties Pages 4252-4261 Michael Decker, Birgit Kraus and Jörg Heilmann

8.
Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin αvβ3 and αvβ5 ligands Pages 4262-4271 Maria Salvati, Franca M. Cordero, Federica Pisaneschi, Fabrizio Melani, Paola Gratteri, Nicoletta Cini, Anna Bottoncetti and Alberto Brandi

9.
Co-existence of α-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development Pages 4272-4285 Kosuke Dodo, Atsushi Aoyama, Tomomi Noguchi-Yachide, Makoto Makishima, Hiroyuki Miyachi and Yuichi Hashimoto

10.
Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity Pages 4286-4293 Susanne Vogel, Susanne Ohmayer, Gabi Brunner and Jörg Heilmann

11.
Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class Pages 4294-4303 Canan Kuş, Gülgün Ayhan-Kılcıgil, Süheyla Özbey, F. Betül Kaynak, Melek Kaya, Tülay Çoban and Benay Can-Eke

12.
Syntheses of 4,6′-epoxymorphinan derivatives and their pharmacologies Pages 4304-4312 Toru Nemoto, Hideaki Fujii, Minoru Narita, Kan Miyoshi, Atsushi Nakamura, Tsutomu Suzuki and Hiroshi Nagase

13.
Potential antitumoral properties of a new copper complex with santonic acid Pages 4313-4322 Patricia A.M. Williams, Juan Zinczuk, Daniel A. Barrio, Oscar E. Piro, Otaciro R. Nascimento and Susana B. Etcheverry

14.
NMR evaluation of adipocyte fatty acid binding protein (aP2) with R- and S-ibuprofen Pages 4323-4330 Guoyun Bai, Huaping Mo and Michael Shapiro

15.
Inhibitors of DNA polymerase β: Activity and mechanism Pages 4331-4340 Zhijie Gao, David J. Maloney, Larisa M. Dedkova and Sidney M. Hecht

16.
Internalisation of the μ-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues Pages 4341-4346 Mark P. Del Borgo, Joanne T. Blanchfield and Istvan Toth

17.
Structure–antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues Pages 4347-4358 Marcelo F. Masman, Csaba Somlai, Francisco M. Garibotto, Ana M. Rodríguez, Agustina de la Iglesia, Susana A. Zacchino, Botond Penke and Ricardo D. Enriz

18.
Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist Pages 4359-4366 Kazunari Sakagami, Akito Yasuhara, Shigeyuki Chaki, Ryoko Yoshikawa, Yasunori Kawakita, Akio Saito, Takeo Taguchi and Atsuro Nakazato

19.
Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers Pages 4367-4377 F. Scott Kimball, Brandon J. Turunen, Keith C. Ellis, Richard H. Himes and Gunda I. Georg

20.
Computational modeling study of functional microdomains in cannabinoid receptor type 1 Pages 4378-4389 Angel Gonzalez, Leonardo Sepulveda Duran, Raul Araya-Secchi, Jose A. Garate, C. David Pessoa-Mahana, Carlos F. Lagos and Tomas Perez-Acle

21.
DNA threading bis(9-aminoacridine-4-carboxamides): Effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest Pages 4390-4400 Zhicong He, Xianyong Bu, Alexandra Eleftheriou, Malik Zihlif, Zhang Qing, Bernard W. Stewart and Laurence P.G. Wakelin

22.
Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-Aryl-2-propenyl)leucomycin analogues Pages 4401-4418 Takeshi Furuuchi, Tomoaki Miura, Ken-ichi Kurihara, Takuji Yoshida, Takashi Watanabe and Keiichi Ajito

23.
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles Pages 4419-4430 Elisabeth Conchon, Fabrice Anizon, Bettina Aboab, Roy M. Golsteyn, Stéphane Léonce, Bruno Pfeiffer and Michelle Prudhomme

24.
Synthesis and antibacterial activity of egonol derivatives Pages 4431-4437 Safiye Emirdağ Öztürk, Yurdanur Akgül and Hüseyin Anıl

25.
Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1: Templates for design Pages 4438-4456 Gillian M. Allan, Nigel Vicker, Harshani R. Lawrence, Helena J. Tutill, Joanna M. Day, Marion Huchet, Eric Ferrandis, Michael J. Reed, Atul Purohit and Barry V.L. Potter

26.
Labeling, characterization, and in vivo localization of a new 90Y-based phosphonate chelate 2,3-dicarboxypropane-1,1-diphosphonic acid for the treatment of bone metastases: Comparison with 99mTc–DPD complex Pages 4457-4465 Divna Dj. Djokić, Drina Lj. Janković and Nadežda S. Nikolić

27.
Identification of neomycin B-binding site in T box antiterminator model RNA Pages 4466-4470 Rajaneesh Anupam, Leyna Denapoli, Abigael Muchenditsi and Jennifer V. Hines

28.
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: Synthesis, pharmacological and molecular modeling studies Pages 4471-4489 Gabriella Guerrini, Giovanna Ciciani, Giovanni Cambi, Fabrizio Bruni, Silvia Selleri, Fabrizio Melani, Marina Montali, Claudia Martini, Carla Ghelardini, Monica Norcini and Annarella Costanzo

29.
Investigating biological activity spectrum for novel quinoline analogues 2: Hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity Pages 4490-4499 Robert Musiol, Dominik Tabak, Halina Niedbala, Barbara Podeszwa, Josef Jampilek, Katarina Kralova, Jiri Dohnal, Jacek Finster, Agnieszka Mencel and Jaroslaw Polanski

30.
Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation Pages 4500-4508 Tomohiro Itoh, Kenji Ohguchi, Munekazu Iinuma, Yoshinori Nozawa and Yukihiro Akao

31.
Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines Pages 4509-4515 Mina Behrouzi-Fardmoghadam, Fatemeh Poorrajab, Sussan Kaboudanian Ardestani, Saeed Emami, Abbas Shafiee and Alireza Foroumadi

32.
Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives Pages 4516-4522 Daniele Zampieri, Maria Grazia Mamolo, Erik Laurini, Giuditta Scialino, Elena Banfi and Luciano Vio

33.
Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents Pages 4523-4531 Theano Fotopoulou, Efstathios K. Iliodromitis, Maria Koufaki, Andrew Tsotinis, Anastasia Zoga, Vassilis Gizas, Anastasia Pyriochou, Andreas Papapetropoulos, Ioanna Andreadou and Dimitrios Th Kremastinos

34.
Benzofused N-substituted cyclic enediynes: Activation and DNA-cleavage potential Pages 4532-4537 Amit Basak and Moumita Kar

35.
Synthesis and biological activities of 2-oxocycloalkylsulfonamides Pages 4538-4544 Xinghai Li, Xinling Yang, Xiaomei Liang, Zhenpeng Kai, Huizu Yuan, Dekai Yuan, Jianjun Zhang, Ruiqing Wang, Fuxiang Ran, Shuhua Qi, Yun Ling, Fuheng Chen and Daoquan Wang

36.
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition Pages 4545-4550 Jin Sung Kim, Hee-Kyung Rhee, Hyen Joo Park, Sang Kook Lee, Chong-Ock Lee and Hea-Young Park Choo

37.
The role of methylglyoxal in the non-enzymatic conversion of tryptophan, its methyl ester and tryptamine to 1-acetyl-β-carbolines Pages 4551-4562 Ina Nemet and Lidija Varga-Defterdarović

38.
Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines Pages 4563-4568 Attila Sipos, Csaba Csutorás, Sándor Berényi, Ain Uustare and Ago Rinken

39.
Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity Pages 4569-4578 Ahmad M. Farag, Abdelrahman S. Mayhoub, Saber E. Barakat and Ashraf H. Bayomi

40.
Proteasome inhibition by peptide-semicarbazones Pages 4579-4588 Johann Leban, Marcus Blisse, Babett Krauss, Sandra Rath, Roland Baumgartner and Markus H.J. Seifert

41.
Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids Pages 4589-4593 Wendy R. Russell, Lorraine Scobbie, Garry G. Duthie and Andrew Chesson

42.
Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases β and λ from Talaromyces sp. Pages 4594-4599 Takuma Kimura, Masayuki Nishida, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida and Yoshiyuki Mizushina

43.
Affinity purification and characterization of a key enzyme responsible for circadian rhythmic control of nyctinasty in Lespedeza cuneata L Pages 4600-4616 Eisuke Kato, Takehiko Sasaki and Minoru Ueda

44.
Synthesis, cytotoxic activities and structure–activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives Pages 4617-4625 Yu Cheng, Lin-Kun An, Ning Wu, Xiao-Dong Wang, Xian-Zhang Bu, Zhi-Shu Huang and Lian-Quan Gu

45.
Synthesis and structure–activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein Pages 4626-4651 Hiteshkumar D. Jain, Chunchun Zhang, Shuo Zhou, Hao Zhou, Jun Ma, Xiaoxiang Liu, Xuebin Liao, Amy M. Deveau, Christine M. Dieckhaus, Michael A. Johnson, Kirsten S. Smith, Timothy L. Macdonald, Hideaki Kakeya, Hiroyuki Osada and James M. Cook

46.
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease Pages 4652-4660 Yi-Ming Shao, Wen-Bin Yang, Tun-Hsun Kuo, Keng-Chang Tsai, Chun-Hung Lin, An-Suei Yang, Po-Huang Liang and Chi-Huey Wong

47.
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands Pages 4661-4669 Matthew A. Parker, Deborah M. Kurrasch and David E. Nichols

48.
Synthesis and inhibitory activity of oligosaccharide thiazolines as a class of mechanism-based inhibitors for endo-β-N-acetylglucosaminidases Pages 4670-4675 Bing Li, Kaoru Takegawa, Tadashi Suzuki, Kenji Yamamoto and Lai-Xi Wang

49.
Identification of novel ligands for the RNA pseudoknot that regulate −1 ribosomal frameshifting Pages 4676-4684 So-Jung Park, Young Hoon Jung, Yang-Gyun Kim and Hyun-Ju Park

50.
Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin Pages 4685-4698 Shinichi Sato, Masashi Tetsuhashi, Keiko Sekine, Hiroyuki Miyachi, Mikihiko Naito, Yuichi Hashimoto and Hiroshi Aoyama

51.
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2) Pages 4699-4714 Yasutomi Asano, Shuji Kitamura, Taiichi Ohra, Fumio Itoh, Masahiro Kajino, Tomoko Tamura, Manami Kaneko, Shota Ikeda, Hideki Igata, Tomohiro Kawamoto, Satoshi Sogabe, Shin-ichi Matsumoto, Toshimasa Tanaka, Masashi Yamaguchi, Hiroyuki Kimura and Shoji Fukumoto

52.
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1) Pages 4715-4732 Yasutomi Asano, Shuji Kitamura, Taiichi Ohra, Kazuyoshi Aso, Hideki Igata, Tomoko Tamura, Tomohiro Kawamoto, Toshimasa Tanaka, Satoshi Sogabe, Shin-ichi Matsumoto, Masashi Yamaguchi, Hiroyuki Kimura and Fumio Itoh

53.
Synthesis and anti-HIV1 biological activity of novel 5″-ATSAO compounds Pages 4733-4741 Cyrille Tomassi, Albert Nguyen Van Nhien, José Marco-Contelles, Jan Balzarini, Christophe Pannecouque, Erik De Clercq and Denis Postel

54.
Bioorganic & Medicinal Chemistry Reviews and Perspectives Pages 4742-4744

Toxicology and Applied Pharmacology: Vol 228, Issue 3,

2008-04-28T10:14:00.000+01:00

REGULAR ARTICLES

2.
Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts — A comparative study Pages 269-276 J.A. van Meeuwen, S. Nijmeijer, T. Mutarapat, S. Ruchirawat, P.C. de Jong, A.H. Piersma and M. van den Berg

3.
The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress Pages 277-285 Chiara Riganti, Costanzo Costamagna, Sophie Doublier, Erica Miraglia, Manuela Polimeni, Amalia Bosia and Dario Ghigo

4.
Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium Pages 286-294 Zhiwei Liu, Xinyuan Yu and Zahir A. Shaikh

5.
Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity Pages 295-300 Jin Seok Kang, Hideki Wanibuchi, Keiichirou Morimura, Rawiwan Wongpoomchai, Yaowares Chusiri, Frank J. Gonzalez and Shoji Fukushima

6.
Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish Pages 301-314 Demetrio Raldúa, Michèle André and Patrick J. Babin

7.
Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice Pages 315-325 Cordelia J. Barrick, Ming Yu, Hann-Hsiang Chao and David W. Threadgill

8.
In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 mice Pages 326-333 Joanne Wan and Louise M. Winn

9.
Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation Pages 334-342 Eva Martínez-García, Marta Irigoyen, Elena Ansó, Juan José Martínez-Irujo and Ana Rouzaut

10.
Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity Pages 343-350 Yong Pil Hwang, Eun Hee Han, Jae Ho Choi, Hyung Gyun Kim, Kyung Jin Lee, Tae Cheon Jeong, Eung Seok Lee and Hye Gwang Jeong

11.
The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation Pages 351-363 Changcheng Song, Zhen Xiao, Kunio Nagashima, Chou-Chi H. Li, Stephen J. Lockett, Ren-Ming Dai, Edward H. Cho, Thomas P. Conrads, Timothy D. Veenstra, Nancy H. Colburn, Qing Wang and Ji Ming Wang

12.
Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: Procainamide-induced autophagic cell vacuolization Pages 364-377 Guillaume Morissette, Robert Lodge and François Marceau

13.
Assessment of semen function and lipid peroxidation among lead exposed men Pages 378-384 Aleksandra Kasperczyk, Sławomir Kasperczyk, Stanisław Horak, Alina Ostałowska, Ewa Grucka-Mamczar, Ewa Romuk, Anita Olejek and Ewa Birkner

14.
Modulation of DNA polymerase beta-dependent base excision repair in cultured human cells after low dose exposure to arsenite Pages 385-394 Peter Sykora and Elizabeth T. Snow

15.
Suppression of a DNA base excision repair gene, hOGG1, increases bleomycin sensitivity of human lung cancer cell line Pages 395-402 Mei Wu, Zunzhen Zhang and Wangjun Che

16.
Contents Page OBC

Regulatory Toxicology and Pharmacology: Vol 50, Issue 3

2008-04-28T10:12:00.000+01:00

REGULAR ARTICLES

2.
Effects of MTBE on the reported incidence of Leydig cell tumors in Sprague–Dawley rats: Range of possible Poly-3 results Pages 273-284 Julie E. Goodman, David Gaylor, Leslie A. Beyer, Lorenz R. Rhomberg and Barbara D. Beck

3.
An evaluation of the genotoxicity of the antitussive drug Dextromethorphan Pages 285-293 Marilyn J. Aardema, Steven H. Robison, David Gatehouse and Gail Johnston

4.
Preclinical safety evaluation of IFNα2a-NGR Pages 294-302 Jieru Meng, Zhen Yan, Yongjie Wu, Mingtang Gao, Wenguang Li, Fei Gao, Hongxing Wang, Wei Han and Yingqi Zhang

5.
Safety assessment of 2-ethyl-3,(5 or 6) dimethylpyrazine as a food ingredient Pages 303-312 George A. Burdock and Ioana G. Carabin

6.
Defining maximum levels of higher alcohols in alcoholic beverages and surrogate alcohol products Pages 313-321 Dirk W. Lachenmeier, Simone Haupt and Katja Schulz

7.
Mutagenicity assessment of acrylate and methacrylate compounds and implications for regulatory toxicology requirements Pages 322-335 F.R. Johannsen, Barbara Vogt, Maureen Waite and Randy Deskin

8.
Improving the quality of risk assessments in Canada using a principle-based approach Pages 336-344 P.M. Forristal, D.L. Wilke and L.S. McCarty

9.
A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development Pages 345-352 Sally Robinson, Jean-Luc Delongeas, Elizabeth Donald, David Dreher, Matthias Festag, Sophie Kervyn, Ann Lampo, Kamil Nahas, Vicente Nogues, Deborah Ockert, Kirsty Quinn, Sally Old, Nigel Pickersgill, Kev Somers, Claudia Stark, Peter Stei, Lynne Waterson and Kathryn Chapman

10.
In vitro activity of dermaseptin S4 derivatives against genital infections pathogens Pages 353-358 Amira Zairi, Frédéric Tangy, Souhir Saadi and Khaled Hani

11.
Could charcoal filtration of cigarette smoke reduce smoking-induced disease? A review of the literature Pages 359-365 Christopher R.E. Coggins and Charles L. Gaworski

12.
Modeling of DR CALUX® bioassay response to screen PCDDs, PCDFs, and dioxin-like PCBs in farm milk from dairy herds Pages 366-375 Igor Fochi, Gianfranco Brambilla, Stefania P. De Filippis, Silvia De Luca, Gianfranco Diletti, Annarita Fulgenzi, Pasquale Gallo, Nicola Iacovella, Giampiero Scortichini, Luigi Serpe, Floriana Vinci and Alessandro di Domenico

13.
Risk assessment for the amino acids taurine, l-glutamine and l-arginine Pages 376-399 Andrew Shao and John N. Hathcock

14.
Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps Pages 400-411 George Loizou, Martin Spendiff, Hugh A. Barton, Jos Bessems, Frédéric Y. Bois, Michel Bouvier d’Yvoire, Harrie Buist, Harvey J. Clewell III, Bette Meek, Ursula Gundert-Remy, Gerhard Goerlitz and Walter Schmitt

15.
Towards more efficient testing strategies—Analyzing the efficiency of toxicity data requirements in relation to the criteria for classification and labelling Pages 412-419 Anna Nordberg, Christina Rudén and Sven Ove Hansson

16.
Human health risk assessments for three neuropharmaceutical compounds in surface waters Pages 420-427 Joel P. Bercu, Neil J. Parke, Janice M. Fiori and Roger D. Meyerhoff

LETTERS TO THE EDITOR

17.
MtBE and cancer in animals: Statistical issues with poly-3 survival adjustments for lifetime studies Pages 428-429 Grace E. Kissling, Christopher J. Portier and James Huff

18.
Letter to the Editor Page 430 Barbara Beck

Toxicology in Vitro: Vol 22, Issue 4

2008-04-28T10:06:00.000+01:00

Mechanisms:
2.
Tributyltin (TBT) inhibition of oligomycin-sensitive Mg-ATPase activity in mussel mitochondria Pages 827-836 Alessandra Pagliarani, Patrizia Bandiera, Vittoria Ventrella, Fabiana Trombetti, Maurizio Pirini, Salvatore Nesci and Anna Rosa Borgatti

3.
Oxidative stress might be a mechanism connected with the decreased α7 nicotinic receptor influenced by high-concentration of fluoride in SH-SY5Y neuroblastoma cells Pages 837-843 Qin Gao, Yan-Jie Liu and Zhi-Zhong Guan

4.
Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: Influence of nucleophilic culture media constituents Pages 844-853 Colin A. Thompson and Philip C. Burcham

5.
Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells Pages 854-863 Patricia Marçal da Costa, Paulo Michel Pinheiro Ferreira, Vanderlan da Silva Bolzani, Maysa Furlan, Vânia Aparecida de Freitas Formenton Macedo dos Santos, Joaquim Corsino, Manoel Odorico de Moraes, Letícia Veras Costa-Lotufo, Raquel Carvalho Montenegro and Cláudia Pessoa

6.
Induction of apoptosis by UV-irradiated chlorinated bisphenol A in Jurkat cells Pages 864-872 Yasuko Mutou, Yuko Ibuki, Yoshiyasu Terao, Shuji Kojima and Rensuke Goto

7.
Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line Pages 873-878 Fábio Klamt, Daniel Thompsen Passos, Mauro Antônio Alves Castro, Daniel Pens Gelain, Ivana Grivicich and José Cláudio Fonseca Moreira

8.
Cr (VI) inhibits DNA, RNA and protein syntheses in hepatocytes: Involvement of glutathione reductase, reduced glutathione and DT-diaphorase Pages 879-886 Mekala Gunaratnam and M. Helen Grant

9.
High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes Pages 887-898 Anissa Igoudjil, Julie Massart, Karima Begriche, Véronique Descatoire, Marie-Anne Robin and Bernard Fromenty

10.
Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: Implications for renal safety Pages 899-909 Anke Lühe, Klaus-Peter Künkele, Monika Haiker, Karen Schad, Christine Zihlmann, Frieder Bauss, Laura Suter and Thomas Pfister

11.
Effect of chronic ethanol exposure on the hepatotoxicity of ecstasy in mice: An ex vivo study Pages 910-920 Helena Pontes, Maria João Santos-Marques, Eduarda Fernandes, José Alberto Duarte, Fernando Remião, Félix Carvalho and Maria Lourdes Bastos

12.
Shifted concentration dependency of EpRE- and XRE-mediated gene expression points at monofunctional EpRE-mediated induction by flavonoids at physiologically relevant concentrations Pages 921-926 Yee Y. Lee-Hilz, Sovianne ter Borg, Willem J.H. van Berkel, Ivonne M.C.M. Rietjens and Jac M.M.J.G. Aarts

13.
Genotoxicity of thimerosal in cultured human lymphocytes with and without metabolic activation sister chromatid exchange analysis proliferation index and mitotic index Pages 927-934 Dilek Eke and Ayla Çelik

14.
Antioxidative potential of melatonin against mercury induced intoxication in spermatozoa in vitro Pages 935-942 Mandava V. Rao and Bindu Gangadharan

15.
Tetrabromobisphenol A (TBBPA), induces cell death in TM4 Sertoli cells by modulating Ca2+ transport proteins and causing dysregulation of Ca2+ homeostasis Pages 943-952 Oluseye A. Ogunbayo, Pei F. Lai, Thomas J. Connolly and Francesco Michelangeli

16.
Investigations of the cytotoxicity of epigallocatechin-3-gallate against PC-3 cells in the presence of Cd2+ in vitro Pages 953-960 Lan-cui Zhang, Hai-ning Yu, Shi-li Sun, Jun-guo Yang, Guo-qing He, Hui Ruan and Sheng-rong Shen

17.
Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes Pages 961-967 Katalin Jemnitz, Zsuzsa Veres, Katalin Monostory, László Kóbori and László Vereczkey

18.
2-Deoxy-d-ribose-induced oxidative stress causes apoptosis in human monocytic cells: Prevention by pyridoxal-5′-phosphate Pages 968-979 Amin Ardestani, Razieh Yazdanparast and Abdolfattah Sarraf Nejad

19.
The influence of metallothionein on exposure to metals: An in vitro study on cellular models Pages 980-987 Alessandro Santon, Alessia Formigari and Paola Irato

20.
In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell Pages 988-994 Ryoji Hirota, Kunihiro Akimaru and Hiroyuki Nakamura

21.
Effect of lead on proliferation and neural differentiation of mouse bone marrow-mesenchymal stem cells Pages 995-1001 Shabnam Kermani, Khadijeh Karbalaie, Seyed Hossein Madani, Ali Akbar Jahangirnejad, Mohamadreza Baghaban Eslaminejad, Mohammad Hossein Nasr-Esfahani and Hossein Baharvand

22.
Some characteristics of quercetin-induced cytotoxicity on rat thymocytes under in vitro condition Pages 1002-1007 Yumiko Nishimura, Toshihisa B. Oyama, Yoko Sakanashi, Tomohiro M. Oyama, Hiroko Matsui, Yoshiro Okano and Yasuo Oyama

23.
Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells Pages 1008-1017 Jiří Vrba, Petr Doležel, Jaroslav Vičar, Martin Modrianský and Jitka Ulrichová

24.
Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells Pages 1018-1024 Monique Nouailhetas Simon, Anna Karenina Azevedo-Martins, Angélica M. Amanso, Carla R.O. Carvalho and Rui Curi

25.
A bioassay for metals utilizing a human cell line Pages 1025-1031 J. Shea, T. Moran and P.F. Dehn

New methods and models

26.
Genotoxic and cytotoxic effects of manganese chloride in cultured human lymphocytes treated in different phases of cell cycle Pages 1032-1037 P.D.L. Lima, M.C. Vasconcellos, M.O. Bahia, R.C. Montenegro, C.O. Pessoa, L.V. Costa-Lotufo, M.O. Moraes and R.R. Burbano

27.
What you see may not always be what you get – Bioavailability and extrapolation from in vitro tests Pages 1038-1042 Jesper B. Nielsen

28.
Mutagenicity and antimutagenicity of teas used in popular medicine in the salmonella/microsome assay Pages 1043-1049 Rubem Cesar Horn and Vera Maria Ferrão Vargas

29.
Screening and detection of the in vitro agonistic activity of xenobiotics on the retinoic acid receptor Pages 1050-1061 Ryo Kamata, Fujio Shiraishi, Jun-ichi Nishikawa, Junzo Yonemoto and Hiroaki Shiraishi

30.
Inter- and intra-individual variability in human skin barrier function: A large scale retrospective study Pages 1062-1069 Victor M. Meidan and Clive S. Roper

31.
In vitro cytotoxicity of eight β-blockers in human corneal epithelial and retinal pigment epithelial cell lines: Comparison with epidermal keratinocytes and dermal fibroblasts Pages 1070-1076 Hoi I. Cheong, Juanita Johnson, Michel Cormier and Kamran Hosseini

32.
Development and application of a stable HeLa cell line capable of site-specific transgenesis using the Cre-lox system: Establishment and application of a stable TNFRI knockdown cell line to cytotoxicity assay Pages 1077-1087 Fumiyo Saito, Hirofumi Yokota, Yoshihisa Sudo, Yoshikuni Yakabe, Haruko Takeyama and Tadashi Matsunaga

33.
A mathematical model of the in vitro keratinocyte response to chromium and nickel exposure Pages 1088-1093 S.J. Franks, J.P. Ward, M.J. Tindall, J.R. King, A. Curtis and G.S. Evans

34.
Arginase release by primary hepatocytes and liver slices results in rapid conversion of arginine to urea in cell culture media Pages 1094-1098 Stephan J.A.C. Peters, Henk P. Haagsman and Klaske van Norren

35.
A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker Pages 1099-1106 Ming-Hsuang Cho, Andrew Niles, Ruili Huang, James Inglese, Christopher P. Austin, Terry Riss and Menghang Xia

36.
Gene expression profiling of in vitro cultured macrophages after exposure to the respiratory sensitizer hexamethylene diisocyanate Pages 1107-1114 S. Verstraelen, B. Wens, J. Hooyberghs, I. Nelissen, H. Witters, G. Schoeters, P. Van Cauwenberge and R. Van Den Heuvel

Brief communication

37.
Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes Pages 1115-1120 Tsuneyuki Ubagai, Shigeru Tansho, Tadashi Ito and Yasuo Ono

Corrigendum

38.
Corrigendum to “Detection of xenobiotic-induced DNA damage by the comet assay applied to human and rat precision-cut liver slices” [Toxicol. In Vitro 21 (2007) 1134–1142] Page 1121 Janja Plazar, Irena Hreljac, Primož Pirih, Metka Filipič and Geny M.M. Groothuis

39.
Announcement: Ekwall Memorial Award Page 1122

Biochemical Pharmacology: Vol 75, Issue 9,

2008-04-28T09:55:00.000+01:00

2.
Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A) Pages 1689-1696 Tomohiro Terada and Ken-ichi Inui

Anitibiotics and Chemotherapeutics

3.
Histone deacetylase inhibitor SAHA induces ERα degradation in breast cancer MCF-7 cells by CHIP-mediated ubiquitin pathway and inhibits survival signaling Pages 1697-1705 Xin Yi, Wei Wei, Sheng-Yu Wang, Zhi-Yan Du, Yuan-Ji Xu and Xiao-Dan Yu

4.
Suppression of ClC-3 channel expression reduces migration of nasopharyngeal carcinoma cells Pages 1706-1716 Jianwen Mao, Lixin Chen, Bin Xu, Lijing Wang, Hongzhi Li, Jiao Guo, Weidong Li, Sihuai Nie, Tim J.C. Jacob and Liwei Wang

5.
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies Pages 1717-1728 Gong Chen, Huanchen Wang, Howard Robinson, Jiwen Cai, Yiqian Wan and Hengming Ke

6.
Critical role of Bid and Bax in indirubin-3′-monoxime-induced apoptosis in human cancer cells Pages 1729-1742 Jie Shi and Han-Ming Shen

7.
A facile method to screen inhibitors of protein–protein interactions including MDM2–p53 displayed on T7 phage Pages 1743-1750 Kazutomo Ishi and Fumio Sugawara

8.
Implication of NAG-1 in synergistic induction of apoptosis by combined treatment of sodium salicylate and PI3K/MEK1/2 inhibitors in A549 human lung adenocarcinoma cells Pages 1751-1760 Cho Hee Kim, Min Young Kim, Ji Young Moon, Ji Won Hwang, Su Yeon Lee, Young Mi Joo, Song Iy Han, Hye Gyeong Park and Ho Sung Kang

9.
STI571/doxorubicin concentration-dependent switch for diverse caspase actions in CML cell line K562 Pages 1761-1773 Malgorzata Czyz, Justyna Jakubowska and Malgorzata Sztiller-Sikorska

10.
Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines Pages 1774-1782 Lynne M. Howells, Christopher P. Neal, Mhairi C. Brown, David P. Berry and Margaret M. Manson

11.
SP1-regulated p27/Kip1 gene expression is involved in terbinafine-induced human A431 cancer cell differentiation: An in vitro and in vivo study Pages 1783-1796 Ching-Shui Huang, Wei-Lu Ho, Wen-Sen Lee, Ming-Thau Sheu, Ying-Jan Wang, Shih-Hsin Tu, Rong-Jane Chen, Jan-Show Chu, Li-Ching Chen, Chia-Hwa Lee, How Tseng, Yuan-Soon Ho and Chih-Hsiung Wu

Cardiovascular Pharmacology

12.
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy Pages 1797-1806 Rajarajan A. Thandavarayan, Kenichi Watanabe, Meilei Ma, Punniyakoti T. Veeraveedu, Narasimman Gurusamy, Suresh S. Palaniyandi, Shaosong Zhang, Anthony J. Muslin, Makoto Kodama and Yoshifusa Aizawa

13.
Aspirin inhibits human bradykinin B2 receptor ligand binding function Pages 1807-1816 Joëlle Gardes, Stéphanie Michineau, Anne Pizard, François Alhenc-Gelas and Rabary M. Rajerison

Inflammation and Immunopharmacology

14.
Inhibitory effect of fluoxetine on lymphoma growth through the modulation of antitumor T-cell response by serotonin-dependent and independent mechanisms Pages 1817-1826 Luciana Romina Frick, María Laura Palumbo, María Paula Zappia, Marcela Adriana Brocco, Graciela Alicia Cremaschi and Ana María Genaro

Metabolic Disorders and Endocrinology

15.
Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus Pages 1827-1834 Renato Tavares dos Santos Pereira, Catarina Segreti Porto, Rosely Oliveira Godinho and Fernando Maurício Francis Abdalla

Neuropharmacology

16.
Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions Pages 1835-1847 Gang Zhao, Shao-Yun Zang, Xiang-Wei Zheng, Xiao-Hua Zhang and Li-He Guo

Pharmacokinetics and Drug Metabolism

17.
Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons Pages 1848-1857 Ru Yan, Tatiana N. Nanovskaya, Olga L. Zharikova, Donald R. Mattison, Gary D.V. Hankins and Mahmoud S. Ahmed

18.
3,3′-Diindolylmethane reduces levels of HIF-1α and HIF-1 activity in hypoxic cultured human cancer cells Pages 1858-1867 Jacques E. Riby, Gary L. Firestone and Leonard F. Bjeldanes

Bioorganic and Medicinal Chemistry Letters: Vol 18, Issue 8

2008-04-28T09:49:00.000+01:00

1.
Editorial board Page IFC

2.
Graphical contents list Pages 2513-2524

3.
Design and campaign synthesis of pyridine-based histone deacetylase inhibitors Pages 2525-2529 David M. Andrews, Keith M. Gibson, Mark A. Graham, Zbigniew S. Matusiak, Craig A. Roberts, Elaine S.E. Stokes, Madeleine C. Brady and Christine M. Chresta

4.
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities Pages 2530-2535 Antonello Mai, Andrea Perrone, Angela Nebbioso, Dante Rotili, Sergio Valente, Maria Tardugno, Silvio Massa, Floriana De Bellis and Lucia Altucci

5.
Tetrazole based amides as growth hormone secretagogues Pages 2536-2539 James J. Li, Haixia Wang, Jun Li, Fucheng Qu, Stephen G. Swartz, Andrés S. Hernández, Scott A. Biller, Jeffrey A. Robl, Joseph A. Tino, Dorothy Slusarchyk, Ramakrishna Seethala, Paul Sleph, Mujing Yan, Gary Grover, Neil Flynn, Brian J. Murphy and David Gordon

6.
Use of γ-aminopropyl-coated glass surface for the patterning of oligonucleotides through oxime bond formation Pages 2540-2543 Nabil Dendane, Antoine Hoang, Eric Defrancq, Françoise Vinet and Pascal Dumy

7.
Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists Pages 2544-2548 J. Kent Barbay, Yong Gong, Mieke Buntinx, Jian Li, Concha Claes, Pamela J. Hornby, Guy Van Lommen, Jean Van Wauwe and Wei He

8.
Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: A cyclic tetrapeptide scaffold Pages 2549-2554 Erinprit K. Singh, Suchitra Ravula, Chung-Mao Pan, Po-Shen Pan, Robert C. Vasko, Stephanie A. Lapera, Sujith V.W. Weerasinghe, Mary Kay H. Pflum and Shelli R. McAlpine

9.
Design of high-affinity peptide conjugates with optimized fluorescence quantum yield as markers for small peptide transporter PEPT1 (SLC15A1) Pages 2555-2557 Praveen M. Bahadduri, Abhijit Ray, Akash Khandelwal and Peter W. Swaan

10.
Synthesis and antimicrobial activity of 7α-amino-23,24-bisnor-5α-cholan-22-ol derivatives Pages 2558-2561 Sharaf Nawaz Khan, Young Mee Jung, Bong Jin Kim, Heeyeong Cho, Jinho Lee and Hong-Seok Kim

11.
Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition Pages 2562-2566 Paul V. Fish, Christopher Deur, Xinmin Gan, Keri Greene, David Hoople, Malcolm Mackenny, Kimberly S. Para, Keith Reeves, Thomas Ryckmans, Cory Stiff, Alan Stobie, Florian Wakenhut and Gavin A. Whitlock

12.
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide–isozyme II adduct Pages 2567-2573 Claudia Temperini, Alessandro Cecchi, Andrea Scozzafava and Claudiu T. Supuran

13.
5-Sulfonyl-benzimidazoles as selective CB2 agonists Pages 2574-2579 Bie M.P. Verbist, Michel A.J. De Cleyn, Michel Surkyn, Erwin Fraiponts, Jeroen Aerssens, Marjoleen J.M.A. Nijsen and Harrie J.M. Gijsen

14.
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors Pages 2580-2584 David M. Andrews, Elaine S.E. Stokes, Greg R. Carr, Zbigniew S. Matusiak, Craig A. Roberts, Michael J. Waring, Madeleine C. Brady, Christine M. Chresta and Simon J. East

15.
Synthesis and antimicrobial properties of Monensin A esters Pages 2585-2589 Adam Huczyński, Joanna Stefańska, Piotr Przybylski, Bogumil Brzezinski and Franz Bartl

16.
Microarray-based label-free detection of RNA using bispyrene-modified 2′-O-methyl oligoribonucleotide as capture and detection probe Pages 2590-2593 Takashi Sakamoto, Akio Kobori and Akira Murakami

17.
Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity Pages 2594-2598 Ahmed Kamal, P. Praveen Kumar, K. Sreekanth, B.N. Seshadri and P. Ramulu

18.
New chemotypes for cathepsin K inhibitors Pages 2599-2603 Naoki Teno, Osamu Irie, Takahiro Miyake, Keigo Gohda, Miyuki Horiuchi, Sachiyo Tada, Kazuhiko Nonomura, Motohiko Kometani, Genji Iwasaki and Claudia Betschart

19.
Exploring predictive QSAR models for hepatocyte toxicity of phenols using QTMS descriptors Pages 2604-2609 Kunal Roy and Paul L.A. Popelier

20.
4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing Pages 2610-2614 Choong Leol Yoo, Gui Jun Yu, Baoxue Yang, Lori I. Robins, A.S. Verkman and Mark J. Kurth

21.
Synthesis of 4′-modified noraristeromycins to clarify the effect of the 4′-hydroxyl groups for inhibitory activity against S-adenosyl-l-homocysteine hydrolase Pages 2615-2618 Takayuki Ando, Kenji Kojima, Praveen Chahota, Atsushi Kozaki, Nikalje D. Milind and Yukio Kitade

22.
Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia Pages 2619-2623 Cheng-Zhu Wu, Seong Su Hong, Xing Fu Cai, Nguyen Tien Dat, Ji-Xing Nan, Bang Yeon Hwang, Jung Joon Lee and Dongho Lee

23.
Selective vasodilatation effect of sargahydroquinoic acid, an active constituent of Sargassum micracanthum, on the basilar arteries of rabbits Pages 2624-2627 Byong-Gon Park, Woon-Seob Shin, Yumi Um, Sungsik Cho, Gab-Man Park, Dong-Soo Yeon, Seong-Chun Kwon, Jungyeob Ham, Byoung Wook Choi and Seokjoon Lee

24.
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Pages 2628-2632 Joshua Roth, Franck Madoux, Peter Hodder and William R. Roush

25.
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives Pages 2633-2639 Gayathri Chadalapaka, Indira Jutooru, Alan McAlees, Tom Stefanac and Stephen Safe

26.
2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization via array synthesis Pages 2640-2644 Lalgudi S. Harikrishnan, Muthoni G. Kamau, Timothy F. Herpin, George C. Morton, Yalei Liu, Christopher B. Cooper, Mark E. Salvati, Jennifer X. Qiao, Tammy C. Wang, Leonard P. Adam, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Ramakrishna Seethala, Tara L. Peterson, David S. Nirschl, Arthur V. Miller, Carolyn A. Weigelt, Kingsley K. Appiah, Jonathan C. O’Connell and R. Michael Lawrence

27.
Novel antibacterial azetidine lincosamides Pages 2645-2648 Hardwin O’Dowd, Jason G. Lewis, Joaquim Trias, Rumi Asano, Johanne Blais, Sara L. Lopez, Craig K. Park, Charlotte Wu, Wen Wang and Mikhail F. Gordeev

28.
N-d-Aldopentofuranosyl-N′-[p-(isoamyloxy)phenyl]-thiourea derivatives: Potential anti-TB therapeutic agents Pages 2649-2651 Avraham Liav, Shiva K. Angala, Patrick J. Brennan and Mary Jackson

29.
Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors Pages 2652-2657 Jagabandhu Das, Robert V. Moquin, Sidney Pitt, Rosemary Zhang, Ding Ren Shen, Kim W. McIntyre, Kathleen Gillooly, Arthur M. Doweyko, John S. Sack, Hongjian Zhang, Susan E. Kiefer, Kevin Kish, Murray McKinnon, Joel C. Barrish, John H. Dodd, Gary L. Schieven and Katerina Leftheris

30.
Novel bisbenzimidazoles with antileishmanial effectiveness Pages 2658-2661 Annie Mayence, Aurélie Pietka, Margaret S. Collins, Melanie T. Cushion, Babu L. Tekwani, Tien L. Huang and Jean Jacques Vanden Eynde

31.
Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis Pages 2662-2668 Karen L. Stirrett, Julian A. Ferreras, Venkatesan Jayaprakash, Barij N. Sinha, Tao Ren and Luis E.N. Quadri

32.
Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors Pages 2669-2674 Anna Di Fiore, Carlo Pedone, Jochen Antel, Harald Waldeck, Andreas Witte, Michael Wurl, Andrea Scozzafava, Claudiu T. Supuran and Giuseppina De Simone

33.
Alkyne–quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD Pages 2675-2678 Jean-Philippe Starck, Laurent Provins, Bernard Christophe, Michel Gillard, Sophie Jadot, Patrick Lo Brutto, Luc Quéré, Patrice Talaga and Michel Guyaux

34.
A novel bifunctional maleimido CHX-A″ chelator for conjugation to thiol-containing biomolecules Pages 2679-2683 Heng Xu, Kwamena E. Baidoo, Karen J. Wong and Martin W. Brechbiel

35.
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping Pages 2684-2690 Adrian Hall, Andy Billinton, Susan H. Brown, Anita Chowdhury, Gerard M.P. Giblin, Paul Goldsmith, David N. Hurst, Alan Naylor, Sadhana Patel, Tiziana Scoccitti and Pamela J. Theobald

36.
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors Pages 2691-2695 Vijaya Gracias, Zhiqin Ji, Irini Akritopoulou-Zanze, Cele Abad-Zapatero, Jeffrey R. Huth, Danying Song, Philip J. Hajduk, Eric F. Johnson, Keith B. Glaser, Patrick A. Marcotte, Lori Pease, Nirupama B. Soni, Kent D. Stewart, Steven K. Davidsen, Michael R. Michaelides and Stevan W. Djuric

37.
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold Pages 2696-2700 Christian Beaulieu, Daniel Guay, Zhaoyin Wang, Yves Leblanc, Patrick Roy, Claude Dufresne, Robert Zamboni, Carl Berthelette, Stephen Day, Nancy Tsou, Danielle Denis, Gillian Greig, Marie-Claude Mathieu and Gary O’Neill

38.
A molecular modeling study of the interaction of 2′-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase Pages 2701-2708 Adam Jarmuła, Anna Dowierciał and Wojciech Rode

39.
Development of 2-tbutyl-N-methyl pyrimidones as potent inhibitors of HIV integrase Pages 2709-2713 M. Emilia Di Francesco, Paola Pace, Fabrizio Fiore, Francesca Naimo, Fabio Bonelli, Michael Rowley and Vincenzo Summa

40.
Pyrano-[2,3b]-pyridines as potassium channel antagonists Pages 2714-2718 Heather J. Finlay, John Lloyd, Michael Nyman, Mary Lee Conder, Tonya West, Paul Levesque and Karnail Atwal

41.
PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold Pages 2719-2724 Christopher P. Holmes, Xianfeng Li, Yijun Pan, Caiding Xu, Ashok Bhandari, Claire M. Moody, Joy A. Miguel, Steven W. Ferla, M. Nuria De Francisco, Brian T. Frederick, Siqun Zhou, Natalie Macher, Larry Jang, Jennifer D. Irvine and J. Russell Grove

42.
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists Pages 2725-2729 Thomas J. Woltering, Jürgen Wichmann, Erwin Goetschi, Geo Adam, James N.C. Kew, Frédéric Knoflach, Theresa M. Ballard, Jörg Huwyler, Vincent Mutel and Silvia Gatti

43.
N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1) Pages 2730-2734 Michele C. Jetter, James J. McNally, Mark A. Youngman, Mark E. McDonnell, Adrienne E. Dubin, Nadia Nasser, Sui-Po Zhang, Ellen E. Codd, Ray W. Colburn, Dennis R. Stone, Michael R. Brandt, Christopher M. Flores and Scott L. Dax

44.
Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase Pages 2735-2738 Pamela L. Donner, Qinghua Xie, John K. Pratt, Clarence J. Maring, Warren Kati, Wen Jiang, Yaya Liu, Gennadiy Koev, Sherie Masse, Debra Montgomery, Akhter Molla and Dale J. Kempf

45.
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38α MAP kinase inhibitors Pages 2739-2744 Stephen T. Wrobleski, Shuqun Lin, John Hynes Jr., Hong Wu, Sidney Pitt, Ding Ren Shen, Rosemary Zhang, Kathleen M. Gillooly, David J. Shuster, Kim W. McIntyre, Arthur M. Doweyko, Kevin F. Kish, Jeffrey A. Tredup, Gerald J. Duke, John S. Sack, Murray McKinnon, John Dodd, Joel C. Barrish, Gary L. Schieven and Katerina Leftheris

46.
Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor Pages 2745-2750 John T. Randolph, Xiaolin Zhang, Peggy P. Huang, Larry L. Klein, Kevin A. Kurtz, Alex K. Konstantinidis, Wenping He, Warren M. Kati and Dale J. Kempf

Toxicology Letters: Vol 178, Issue 1

2008-04-28T09:48:00.000+01:00

Editorial Board Page CO2

2.
Editorial Board Page ii

3.
Disposition of styrene-acrylonitrile (SAN) trimer in female rats: Single dose intravenous and gavage studies Pages 1-8 Michael L. Gargas, Brad Collins, Timothy R. Fennell, Norman F. Gaudette Jr. and Lisa M. Sweeney

4.
Intravenous tolerance of a nanoparticle-based formulation of doxorubicin in healthy rats Pages 9-19 E. Pereverzeva, I. Treschalin, D. Bodyagin, O. Maksimenko, J. Kreuter and S. Gelperina

5.
Differential signatures of protein glycosylation and phosphorylation in human Chang liver cells induced by TCDD treatment Pages 20-28 Ji-Hye Kim, Yu-Jung In, Won Kon Kim, Kwang-Hee Bae, Sunghyun Kang and Sang Chul Lee

6.
Disposition of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and its metabolite 4-bromo-2-hydroxy-5-methoxyphenethylamine in rats after subcutaneous administration Pages 29-36 Miroslava Rohanová, Tomáš Páleníček and Marie Balíková

7.
Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes Pages 37-43 Tom Henkens, Mathieu Vinken, Aneta Lukaszuk, Dirk Tourwé, Tamara Vanhaecke and Vera Rogiers

8.
Studies of the potential genotoxic effects of furoxans: The case of CAS 1609 and of the water-soluble analogue of CHF 2363 Pages 44-51 S. Balbo, L. Lazzarato, A. Di Stilo, R. Fruttero, N. Lombaert and M. Kirsch-Volders

9.
Chloroquine-induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells Pages 52-60 Byung Chul Park, Seung Hee Park, Seung-Hwan Paek, Su-Young Park, Mi-Kyoung Kwak, Han Gon Choi, Chul Soon Yong, Bong Kyu Yoo and Jung-Ae Kim

10.
The microbial PhIP metabolite 7-hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3′,2′:4,5]imidazo[1,2-a]pyrimidin-5-ium chloride (PhIP-M1) induces DNA damage, apoptosis and cell cycle arrest towards Caco-2 cells Pages 61-69 Lynn Vanhaecke, Lara Derycke, Frank Le Curieux, Sofie Lust, Daniel Marzin, Willy Verstraete and Marc Bracke

European Journal of Medicinal Chemistry: Vol 43, Issue 4

2008-04-28T09:41:00.000+01:00

1.
Editorial board Page IFC

2.
Graphical contents list Pages iii-x

Original articles

3.
Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities Pages 675-682 Jong-Keun Son, Long-Xuan Zhao, Arjun Basnet, Pritam Thapa, Radha Karki, Younghwa Na, Yurngdong Jahng, Tae Cheon Jeong, Byeong-Seon Jeong, Chong-Soon Lee and Eung-Seok Lee

4.
Synthesis and in vitro antibacterial activities of novel oxazolidinones Pages 683-693 Brijesh Kumar Srivastava, Mukul R. Jain, Manish Solanki, Rina Soni, Darshan Valani, Sunil Gupta, Bhupendra Mishra, Vijay Takale, Prashant Kapadnis, Harilal Patel, Purvi Pandya, Jayendra Z. Patel and Pankaj R. Patel

5.
Synthesis, computational study and cytotoxic activity of new 4-hydroxycoumarin derivatives Pages 694-706 Stancho Stanchev, Georgi Momekov, Frank Jensen and Ilia Manolov

6.
Synthesis, physicochemical properties and antimicrobial evaluation of new (E)-chalcones Pages 707-713 Z. Nowakowska, B. Kędzia and G. Schroeder

7.
QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES Pages 714-740 A.A. Toropov, A.P. Toropova and I. Raska Jr.

8.
Preparation and characterization of technetium and rhenium tricarbonyl complexes bearing the 4-nitrobenzyl moiety as potential bioreductive diagnostic radiopharmaceuticals. In vitro and in vivo studies Pages 741-748 Javier Giglio, Georgios Patsis, Ioannis Pirmettis, Minas Papadopoulos, Catherine Raptopoulou, Maria Pelecanou, Elsa León, Mercedes González, Hugo Cerecetto and Ana Rey

9.
Synthesis and anticonvulsant activity of some novel 3-aryl amino/amino-4-aryl-5-imino-Δ2-1,2,4-thiadiazoline Pages 749-754 Arun Gupta, Pradeep Mishra, Sushil K. Kashaw, Varsha Jatav and J.P. Stables

10.
Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives Pages 755-762 Fadoua Bouchikhi, Fabrice Anizon and Pascale Moreau

11.
Synthesis and in vivo anti-mutagenic activity of novel melatonin derivatives Pages 763-770 Gamal A. Elmegeed, Wagdy K.B. Khalil, Amira Abdel Raouf and Mervat M. Abdelhalim

12.
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors Pages 771-780 Sanjay Gupta, Lígia M. Rodrigues, Ana P. Esteves, Ana M.F. Oliveira-Campos, M. São José Nascimento, N. Nazareth, Honorina Cidade, Marta P. Neves, Eduarda Fernandes, Madalena Pinto, Nuno M.F.S.A. Cerqueira and Natércia Brás

13.
Towards predictive inhibitor design for the EGFR autophosphorylation activity Pages 781-791 Amor A. San Juan

14.
New amido derivatives as potential BKCa potassium channel activators. XI Pages 792-799 Vincenzo Calderone, Francesca Lidia Fiamingo, Gabriella Amato, Irene Giorgi, Oreste Livi, Alma Martelli and Enrica Martinotti

15.
Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity Pages 800-807 Christian Schlapper, Werner Seebacher, Marcel Kaiser, Reto Brun, Robert Saf and Robert Weis

16.
Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety Pages 808-815 Prakash Karegoudar, D. Jagdeesh Prasad, Mithun Ashok, Manjathuru Mahalinga, Boja Poojary and Bantwal Shivarama Holla

17.
Cyclic nucleotide phosphodiesterase type 4 inhibitors: Evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere Pages 816-829 Pierre Raboisson, Dominique Schultz, Christian Muller, Jean-Marie Reimund, Guillaume Pinna, Romain Mathieu, Philippe Bernard, Quoc-Tuan Do, Renee L. DesJarlais, Hélène Justiano, Claire Lugnier and Jean-Jacques Bourguignon

18.
Molecular modeling studies of phenoxypyrimidinyl imidazoles as p38 kinase inhibitors using QSAR and docking Pages 830-838 G.K. Ravindra, G. Achaiah and G.N. Sastry

19.
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells Pages 839-845 Pal Perjési, Umashankar Das, Erik De Clercq, Jan Balzarini, Masame Kawase, Hiroshi Sakagami, James P. Stables, Tamas Lorand, Zsuzsanna Rozmer and Jonathan R. Dimmock

20.
Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines Pages 846-852 P. Mani Chandrika, T. Yakaiah, A. Raghu Ram Rao, B. Narsaiah, N. Chakra Reddy, V. Sridhar and J. Venkateshwara Rao

21.
Synthesis, properties and photodynamic inactivation of Escherichia coli by novel cationic fullerene C60 derivatives Pages 853-861 Mariana B. Spesia, M. Elisa Milanesio and Edgardo N. Durantini

22.
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase Pages 862-871 Zhong-Lu You, Da-Hua Shi, Chen Xu, Qiang Zhang and Hai-Liang Zhu

23.
Antimycobacterial activity of diphenylpyraline derivatives Pages 872-879 Robert Weis, Johanna Faist, Ulrike di Vora, Klaus Schweiger, Barbara Brandner, Andreas J. Kungl and Werner Seebacher

Short communication

24.
In vitro PAI-1 inhibitory activity of oxalamide derivatives Pages 880-884 Mukul R. Jain, Shankar Shetty, Ganes Chakrabarti, Vrajesh Pandya, Ajay Sharma, Bhavesh Parmar, Soma Srivastava, Mehul Raviya, Hitesh Soni and Pankaj R. Patel

Preliminary communication

25.
Synthesis and anticancer activity of new class of bisphosphonates/phosphanamidates Pages 885-892 Y.B. Kiran, C. Devendranath Reddy, D. Gunasekar, C. Suresh Reddy, Annette Leon and Luiz C.A. Barbosa

Laboratory note

26.
An elegant synthesis of Zetaclausenamide Pages 893-896 Nianchun Ma, Kemei Wu and Liang Huang

Toxicology: Vol 247, Issue 1

2008-04-28T09:40:00.000+01:00

Articles

2.
Adult derived mononuclear bone marrow cells improve survival in a model of acetaminophen-induced acute liver failure in rats Pages 1-5 Maria Cristina Belardinelli, Fernanda Pereira, Guilherme Baldo, Ângela Maria Vicente Tavares, Carlos Oscar Kieling, Themis Reverbel da Silveira, Luise Meurer, Marcos Eugênio Soares Duarte, Roberto Giugliani and Ursula Matte

3.
Increase in intracellular free/bound NAD[P]H as a cause of Cd-induced oxidative stress in the HepG2 cells Pages 6-10 M.S. Yang, D. Li, T. Lin, J.J. Zheng, W. Zheng and J.Y. Qu

4.
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity Pages 11-22 Marie Stiborová, Helena Dračínská, Jana Mizerovská, Eva Frei, Heinz H. Schmeiser, Jiří Hudeček, Petr Hodek, David H. Phillips and Volker M. Arlt

5.
Pro-inflammatory potential of ultrafine particles in mono- and co-cultures of primary cardiac cells Pages 23-32 Annike I. Totlandsdal, Tor Skomedal, Marit Låg, Jan-Bjørn Osnes and Magne Refsnes

6.
Comparative assessment of early acute lung injury in mice and rats exposed to 1,6-hexamethylene diisocyanate–polyisocyanate aerosols Pages 33-45 Jürgen Pauluhn

7.
Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs Pages 46-54 G.M. Meissonnier, J. Laffitte, I. Raymond, E. Benoit, A.-M. Cossalter, P. Pinton, G. Bertin, I.P. Oswald and P. Galtier

8.
Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: A partial role of cytosolic phospholipase A2 and extracellular signal-regulated kinases 1/2 signalling Pages 55-60 L. Umannová, J. Neča, Z. Andrysík, J. Vondráček, B.L. Upham, J.E. Trosko, J. Hofmanová, A. Kozubík and M. Machala

News and Views

9.
Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) Pages 61-72 Rodney R. Dietert and Janice M. Dietert

Toxicology and Applied Pharmacology: Vol 228, Issue 2

2008-04-28T09:39:00.000+01:00

Regular Articles

2.
Involvement of mitogen-activated protein kinases and NFκB in LPS-induced CD40 expression on human monocytic cells Pages 135-143 Weidong Wu, Neil E. Alexis, Xian Chen, Philip A. Bromberg and David B. Peden

3.
SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan Pages 144-155 Ling-I Hsu, Allen W. Chiu, Steven K. Huan, Chi-Ling Chen, Yuan-Hung Wang, Fang-I Hsieh, Wei-Ling Chou, Li-Hua Wang and Chien-Jen Chen

4.
Thermodynamic basis for expressing dose logarithmically Pages 156-157 William J. Waddell

5.
Human inter-individual variability in metabolism and genotoxic response to zidovudine Pages 158-164 Ofelia A. Olivero, Jessica M. Ming, Shreyasi Das, Irma L. Vazquez, Diana L. Richardson, Ainsley Weston and Miriam C. Poirier

6.
Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity Pages 165-178 R.A. Corley, D.M. Wilson, G.C. Hard, K.E. Stebbins, M.J. Bartels, J.J. Soelberg, M.D. Dryzga, R. Gingell, K.E. McMartin and W.M. Snellings

7.
Supression of inflammatory responses by labdane-type diterpenoids Pages 179-189 Natalia Girón, Paqui G. Través, Benjamín Rodríguez, Raquel López-Fontal, Lisardo Boscá, Sonsoles Hortelano and Beatriz de las Heras

8.
Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity Pages 190-199 Qingdong Ke, Thomas P. Ellen and Max Costa

9.
Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes Pages 200-211 Leshuai W. Zhang, William W. Yu, Vicki L. Colvin and Nancy A. Monteiro-Riviere

10.
A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells Pages 212-224 Morgane Gorria, Xavier Tekpli, Mary Rissel, Odile Sergent, Laurence Huc, Nina Landvik, Olivier Fardel, Marie-Thérèse Dimanche-Boitrel, Jørn A. Holme and Dominique Lagadic-Gossmann

11.
Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2 Pages 225-238 Vishakha S. Bhave, Shashikiran Donthamsetty, John R. Latendresse, Levan Muskhelishvili and Harihara M. Mehendale

12.
Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury Pages 239-246 Vishakha S. Bhave, Shashikiran Donthamsetty, John R. Latendresse and Harihara M. Mehendale

13.
Neuronal effects of 4-t-Butylcatechol: A model for catechol-containing antioxidants Pages 247-255 Yi-Ching Lo, Yuxin Liu, Yi-Chin Lin, Yu-Tzu Shih, Chi-Ming Liu and Leo T. Burka

14.
Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: Involvement of Src/EGFR/PI3-K/Akt pathway Pages 256-268 Wei-Ning Lin, Shue-Fen Luo, Chou-Bing Wu, Chih-Chung Lin and Chuen-Mao Yang

15.
Contents Page OBC

Bioorganic and Medicinal Chemistry: Vol 16, Issue 7

2008-04-28T09:38:00.000+01:00

1.
Editorial board Page IFC

2.
Graphical contents list Pages 3463-3481

3.
Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR Pages 3482-3488 Anja Michalczyk, Sabine Klüter, Haridas B. Rode, Jeffrey R. Simard, Christian Grütter, Matthias Rabiller and Daniel Rauh

4.
1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis, biological activity, metabolic stability, and solubility Pages 3489-3500 Alexandra Fritsche, Alwine Schulze Elfringhoff, Jörg Fabian and Matthias Lehr

5.
Synthesis and DNA-cleaving activity of lactenediynes conjugated with DNA-complexing moieties Pages 3501-3518 Luca Banfi, Andrea Basso, Elisabetta Bevilacqua, Valentina Gandolfo, Giuseppe Giannini, Giuseppe Guanti, Loana Musso, Monica Paravidino and Renata Riva

6.
Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent Pages 3519-3529 Puranik Purushottamachar, Aakanksha Khandelwal, Tadas S. Vasaitis, Robert D. Bruno, Lalji K. Gediya and Vincent C.O. Njar

7.
Carbonic anhydrase activators: Activation of the human tumor-associated isozymes IX and XII with amino acids and amines Pages 3530-3536 Silvia Pastorekova, Daniela Vullo, Isao Nishimori, Andrea Scozzafava, Jaromir Pastorek and Claudiu T. Supuran

8.
N-1H-Benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists Pages 3537-3549 Cindy Benod, Guy Subra, Virginie Nahoum, Aude Mallavialle, Jean-François Guichou, Julien Milhau, Samuel Roblés, William Bourguet, Jean-Marc Pascussi, Patrick Balaguer and Alain Chavanieu

9.
Synthetic homoserine lactone-derived sulfonylureas as inhibitors of Vibrio fischeri quorum sensing regulator Pages 3550-3556 Marine Frezza, Laurent Soulère, Sylvie Reverchon, Nicolas Guiliani, Carlos Jerez, Yves Queneau and Alain Doutheau

10.
Stereochemical studies on the novel monoamine oxidase B substrates (1R,6S)- and (1S,6R)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane Pages 3557-3564 Philippe Bissel, Ashraf Khalil, John M. Rimoldi, Kazuo Igarashi, Dale Edmondson, Anthony Miller and Neal Castagnoli Jr.

11.
Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens Pages 3565-3579 Hiroaki Gouda, Yuichi Yanai, Akihiro Sugawara, Toshiaki Sunazuka, Satoshi Ōmura and Shuichi Hirono

12.
Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme Pages 3580-3586 Eui Seok Shin, Jiyoung Park, Jae-Min Shin, Dooho Cho, Si Young Cho, Dong Wook Shin, Mira Ham, Jae Bum Kim and Tae Ryong Lee

13.
Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine Pages 3587-3595 Zhengqiang Wang and Robert Vince

14.
Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A Pages 3596-3601 Si-Hong Wang, Shou-Feng Wang, Wei Xuan, Zong-Hao Zeng, Jing-Yi Jin, Jie Ma and Guan Rong Tian

15.
N-Aroyl-3,5-bis(benzylidene)-4-piperidones: A novel class of antimycobacterial agents Pages 3602-3607 Umashankar Das, Swagatika Das, Brian Bandy, James P. Stables and Jonathan R. Dimmock

16.
Synthesis of curcumin mimics with multidrug resistance reversal activities Pages 3608-3615 Yumi Um, Sungsik Cho, Ho Bum Woo, Yong Kee Kim, Hanna Kim, Jungyeob Ham, Su-Nam Kim, Chan Mug Ahn and Seokjoon Lee

17.
In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin Pages 3616-3625 Andrew C. Bulmer, Joanne T. Blanchfield, Jeff. S. Coombes and Istvan Toth

18.
Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines Pages 3626-3631 Stanton Hon Lung Kok, Roberto Gambari, Chung Hin Chui, Marcus Chun Wah Yuen, Eva Lin, Raymond Siu Ming Wong, Fung Yi Lau, Gregory Yin Ming Cheng, Wing Sze Lam, Sau Hing Chan, Kim Hung Lam, Chor Hing Cheng, Paul Bo Shan Lai, Michael Wing Yiu Yu, Filly Cheung, Johnny Cheuk On Tang and Albert Sun Chi Chan

19.
Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety Pages 3632-3640 Fang Liu, Xiao-Qiong Luo, Bao-An Song, Pinaki S. Bhadury, Song Yang, Lin-Hong Jin, Wei Xue and De-Yu Hu

20.
Antioxidant and cytotoxic activities of canadine: Biological effects and structural aspects Pages 3641-3651 Estela R. Correché, Sebastian A. Andujar, Rita R. Kurdelas, María J. Gómez Lechón, Mónica L. Freile and Ricardo D. Enriz

21.
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation Pages 3652-3660 Andrew J. Wiemer, Jose S. Yu, Larry W. Shull, Rocky J. Barney, Brian M. Wasko, Kimberly M. Lamb, Raymond J. Hohl and David F. Wiemer

22.
Synthesis, antimalarial activity, structure–activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs Pages 3661-3674 Arthur Barazarte, José Camacho, José Domínguez, Gricela Lobo, Neira Gamboa, Juan Rodrigues, Mario V. Capparelli, Ángel Álvarez-Larena, Sebastian Andujar, Daniel Enriz and Jaime Charris

23.
CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors Pages 3675-3686 Shridhar S. Kulkarni, Maulik R. Patel and Tanaji T. Talele

24.
Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones Pages 3687-3693 Jaime A. Valderrama, Hilda Leiva, Jaime A. Rodríguez, Cristina Theoduloz and Guillermo Schmeda-Hirshmann

25.
Methoxylation of 3′,4′-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells Pages 3694-3703 Wang-Fun Fong, Xiao-Ling Shen, Christoph Globisch, Michael Wiese, Guang-Ying Chen, Guo-Yuan Zhu, Zhi-Ling Yu, Anfernee Kai-Wing Tse and Ying-Jie Hu

26.
Platinum(II) complexes with steroidal esters of l-methionine and l-histidine: Synthesis, characterization and cytotoxic activity Pages 3704-3713 Miroslav Kvasnica, Milos Budesinsky, Jana Swaczynova, Vladimir Pouzar and Ladislav Kohout

27.
2-Heteroarylimino-5-benzylidene-4-thiazolidinones analogues of 2-thiazolylimino-5-benzylidene-4-thiazolidinones with antimicrobial activity: Synthesis and structure–activity relationship Pages 3714-3724 Paola Vicini, Athina Geronikaki, Matteo Incerti, Franca Zani, John Dearden and Mark Hewitt

28.
A novel sesquiterpene lactone from Centaurea pullata: Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties Pages 3725-3731 Samah Djeddi, Anastasia Karioti, Marina Sokovic, Catherine Koukoulitsa and Helen Skaltsa

29.
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators Pages 3732-3743 Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, Maria Grazia Perrone, Marialessandra Contino, Carmela Inglese, Mauro Niso, Roberto Perrone, Amalia Azzariti, Grazia Maria Simone and Angelo Paradiso

30.
Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core Pages 3744-3758 Kimberly M. Bonger, Richard J.B.H.N. van den Berg, Annemiek D. Knijnenburg, Laura H. Heitman, Ad P. IJzerman, Julia Oosterom, Cornelis M. Timmers, Herman S. Overkleeft and Gijsbert A. van der Marel

31.
Selective plasma protein binding of antimalarial drugs to α1-acid glycoprotein Pages 3759-3772 Ferenc Zsila, Júlia Visy, György Mády and Ilona Fitos

32.
Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines Pages 3773-3779 Attila Sipos, Béla Kiss, Éva Schmidt, István Greiner and Sándor Berényi

33.
γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity Pages 3780-3790 Kumiko Sako, Hiroshi Aoyama, Shinichi Sato, Yuichi Hashimoto and Masanori Baba

34.
Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells Pages 3791-3799 Claudriana Locatelli, Rober Rosso, Maria C. Santos-Silva, Camila A. de Souza, Marley A. Licínio, Paulo Leal, Maria L. Bazzo, Rosendo A. Yunes and Tânia B. Creczynski–Pasa

35.
Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARα Pages 3800-3808 Cassia S. Mizuno, Guoyi Ma, Shabana Khan, Akshay Patny, Mitchell A. Avery and Agnes M. Rimando

36.
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-l-homocysteine hydrolase Pages 3809-3815 Takayuki Ando, Masafumi Iwata, Fazila Zulfiqar, Tatsuya Miyamoto, Masayuki Nakanishi and Yukio Kitade

37.
The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki–Miyaura cross-coupling reaction Pages 3816-3824 Junfeng Huang, Crina M. Orac, Susan McKay, Dennis B. McKay and Stephen C. Bergmeier

38.
Synthesis of eudistomin D analogues and its effects on adenosine receptors Pages 3825-3830 Haruaki Ishiyama, Kengo Ohshita, Tetsuro Abe, Hiroyasu Nakata and Jun’ichi Kobayashi

39.
Synthesis and GABAA receptor activity of oxygen-bridged neurosteroid analogs Pages 3831-3838 Lautaro D. Alvarez, Adriana S. Veleiro, Ricardo F. Baggio, María T. Garland, Valeria C. Edelsztein, Héctor Coirini and Gerardo Burton

40.
Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors Pages 3839-3847 Jie Zhang, Qiang Wang, Hao Fang, Wenfang Xu, Ailin Liu and Guanhua Du

41.
Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity Pages 3848-3865 Zhengxiang Zhu and John K. Buolamwini

42.
Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase Pages 3866-3870 Akihiko Hatano, Aiko Harano, Yoshikatsu Takigawa, Yasuhiro Naramoto, Keisuke Toda, Yuuichi Nakagomi and Hideyuki Yamada

43.
Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates Pages 3871-3877 Xin-Bin Yang, Jie Feng, Ji Zhang, Zhong-Wei Zhang, Hong-Hui Lin, Li-Hong Zhou and Xiao-Qi Yu

44.
A spectroscopy approach for the study of the interactions of bioactive vanadium species with bovine serum albumin Pages 3878-3886 Evelina G. Ferrer, Alejandra Bosch, Osvaldo Yantorno and Enrique J. Baran

45.
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors Pages 3887-3894 Yue-Ping Wang, Fen-Er Chen, Erik De Clercq, Jan Balzarini and Christophe Pannecouque

46.
Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity Pages 3895-3906 Ahmed Kamal, P. Praveen Kumar, B.N. Seshadri, O. Srinivas, M. Shiva Kumar, Subrata Sen, Nisha Kurian, Aarti S. Juvekar and Surekha M. Zingde

47.
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors Pages 3907-3916 M.V. Ramana Reddy, Vinay K. Billa, Venkat R. Pallela, Muralidhar R. Mallireddigari, Rengasamy Boominathan, Jerome L. Gabriel and E. Premkumar Reddy

48.
Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis Pages 3917-3925 Mark D. Rosen, Michael D. Hack, Brett D. Allison, Victor K. Phuong, Craig R. Woods, Magda F. Morton, Clodagh E. Prendergast, Terrance D. Barrett, Carsten Schubert, Lina Li, Xiaodong Wu, Jiejun Wu, Jamie M. Freedman, Nigel P. Shankley and Michael H. Rabinowitz

49.
Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors Pages 3926-3932 Polyxeni Alexiou, Ioannis Nicolaou, Milan Stefek, Albin Kristl and Vassilis J. Demopoulos

50.
Carbonic anhydrase inhibitors: Inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides Pages 3933-3940 Franciszek Sączewski, Alessio Innocenti, Jarosław Sławiński, Anita Kornicka, Zdzisław Brzozowski, Elżbieta Pomarnacka, Andrea Scozzafava, Claudia Temperini and Claudiu T. Supuran

51.
Novel cyclohexene derivatives as anti-sepsis agents: Synthetic studies and inhibition of NO and cytokine production Pages 3941-3958 Masami Yamada, Takashi Ichikawa, Masayuki Ii, Katsumi Itoh, Norikazu Tamura and Tomoyuki Kitazaki

52.
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds Pages 3959-3968 Brian B. Hasinoff, Hong Liang, Xing Wu, Lynn J. Guziec, Frank S. Guziec Jr., Kyle Marshall and Jack C. Yalowich

53.
Structure–activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects Pages 3969-3975 Ryoko Takasawa, Saki Takahashi, Kazunori Saeki, Satoshi Sunaga, Atsushi Yoshimori and Sei-ichi Tanuma

54.
Cytotoxic activity of proflavine diureas: Synthesis, antitumor, evaluation and DNA binding properties of 1′,1″-(acridin-3,6-diyl)-3′,3″-dialkyldiureas Pages 3976-3984 Mária Kožurková, Danica Sabolová, Ladislav Janovec, Jaromír Mikeš, Ján Koval’, Ján Ungvarský, Miroslava Štefanišinová, Peter Fedoročko, Pavol Kristian and Ján Imrich

55.
Novel 16-membered macrolides modified at C-12 and C-13 positions of midecamycin A1 and miokamycin. Part 1: Synthesis and evaluation of 12,13-carbamate and 12-arylalkylamino-13-hydroxy analogues Pages 3985-4002 Tomoaki Miura, Ken-ichi Kurihara, Takeshi Furuuchi, Takuji Yoshida and Keiichi Ajito

56.
A single thiourea group is not enough to get stable thiourea lipoplexes Pages 4003-4008 Eihab Kabha, Claire Jacquement, Gaëlle Pembouong, Nathalie Mignet, Daniel Scherman and Jean Herscovici

57.
Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones Pages 4009-4018 H. Serra, T. Mendes, M.R. Bronze and Ana Luísa Simplício

58.
A class of novel nitronyl nitroxide labeling basic and acidic amino acids: Synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigations Pages 4019-4028 Jianwei Zhang, Ming Zhao, Guohui Cui and Shiqi Peng

59.
DNA polymerase bypass in vitro and in E. coli of a C-nucleotide analogue of Fapy·dG Pages 4029-4034 Yvonne N. Weledji, Carissa J. Wiederholt, Michael O. Delaney and Marc M. Greenberg

60.
Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands Pages 4035-4051 Kwang-Seop Song, Sung-Han Lee, Hyun Ji Chun, Jong Yup Kim, Myung Eun Jung, Kwangwoo Ahn, Soo-Un Kim, Jeongmin Kim and Jinhwa Lee

61.
A structural analysis of the differential cytotoxicity of chemicals in the NCI-60 cancer cell lines Pages 4052-4063 Suman K. Chakravarti and Gilles Klopman

62.
Modeling and synthesis of novel tight-binding inhibitors of cytochrome P450 2C9 Pages 4064-4074 Chi-Chi Peng, Tom Rushmore, Gregory J. Crouch and Jeffrey P. Jones

63.
Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives Pages 4075-4082 Xin-Hua Liu, Pin Cui, Bao-An Song, Pinaki S. Bhadury, Hai-Liang Zhu and Shi-Fan Wang

64.
Alkyl deoxy-arabino-hexopyranosides: Synthesis, surface properties, and biological activities Pages 4083-4092 Filipa V.M. Silva, Margarida Goulart, Jorge Justino, Ana Neves, Fernando Santos, João Caio, Susana Lucas, Ana Newton, Diana Sacoto, Ester Barbosa, Maria-Soledade Santos and Amélia P. Rauter

65.
Synthesis and structure–activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors Pages 4093-4106 Hiroshi Fukushima, Akira Hiratate, Masato Takahashi, Ayako Mikami, Masako Saito-Hori, Eiji Munetomo, Kiyokazu Kitano, Sumi Chonan, Hidetaka Saito, Akio Suzuki, Yuji Takaoka and Koji Yamamoto

66.
A binary QSAR model for classification of hERG potassium channel blockers Pages 4107-4119 Khac-Minh Thai and Gerhard F. Ecker

67.
Bioactive alkenylphenols from Piper obliquum Pages 4120-4126 Carola Valdivia, Nieves Marquez, John Eriksson, Antonio Vilaseca, Eduardo Muñoz and Olov Sterner

68.
Design and synthesis of cyclic disulfide-bonded antibacterial peptides on the basis of the α helical domain of Tenecin 1, an insect defensin Pages 4127-4137 Hye-sun Ahn, Wonmi Cho, Joung-min Kim, Bishnu Prasad Joshi, Jun-won Park, Chuda Raj Lohani, Hyeongjin Cho and Keun-Hyeung Lee

69.
Structure-based virtual screening against SARS-3CLpro to identify novel non-peptidic hits Pages 4138-4149 Prasenjit Mukherjee, Prashant Desai, Larry Ross, E. Lucile White and Mitchell A. Avery

70.
Design and synthesis of trans 2-(furan-2-yl)vinyl heteroaromatic iodides with antitumour activity Pages 4150-4159 Cosimo Gianluca Fortuna, Vincenza Barresi, Giuliano Berellini and Giuseppe Musumarra

71.
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure–activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates Pages 4160-4172 Sara Cesarini, Andrea Spallarossa, Angelo Ranise, Paola Fossa, Paolo La Colla, Giuseppina Sanna, Gabriella Collu and Roberta Loddo

72.
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Parallel synthesis, molecular modelling and structure–activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate Pages 4173-4185 Sara Cesarini, Andrea Spallarossa, Angelo Ranise, Olga Bruno, Paolo La Colla, Barbara Secci, Gabriella Collu and Roberta Loddo

73.
Erratum to “Novel analogs of d-e-MAPP and B13. Part 1: Synthesis and evaluation as potential anticancer agents” [Bioorg. Med. Chem. 16 (2008) 1015–1031] Page 4186 Zdzislaw M. Szulc, Nalini Mayroo, AiPing Bai, Jacek Bielawski, Xiang Liu, James S. Norris, Yusuf A. Hannun and Alicja Bielawska

74.
Erratum to “Novel analogs of d-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids” [Bioorg. Med. Chem. 16 (2008) 1032–1045] Page 4187 Alicja Bielawska, Jacek Bielawski, Zdzislaw M. Szulc, Nalini Mayroo, Xiang Liu, AiPing Bai, Saeed Elojeimy, Barbara Rembiesa, Jason Pierce, James S. Norris and Yusuf A. Hannun

Bioorganic and Medicinal Chemistry: Vol 16, Issue 6

2008-04-28T09:35:00.000+01:00

1.
Editorial board Page IFC

2.
Graphical contents list Pages 2707-2725

3.
A comparative density-functional study of the reaction mechanism of the O2-dependent coproporphyrinogen III oxidase Pages 2726-2733 Pedro J. Silva and Maria João Ramos

4.
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases Pages 2734-2740 Yasuhiro Minami, Chinami Kuriyama, Kyoko Ikeda, Atsushi Kato, Kenji Takebayashi, Isao Adachi, George W.J. Fleet, Aikkarach Kettawan, Tadashi Okamoto and Naoki Asano

5.
A new generation of adenosine receptor antagonists: From di- to trisubstituted aminopyrimidines Pages 2741-2752 Jacobus P.D. van Veldhoven, Lisa C.W. Chang, Jacobien K. von Frijtag Drabbe Künzel, Thea Mulder-Krieger, Regina Struensee-Link, Margot W. Beukers, Johannes Brussee and Adriaan P. IJzerman

6.
11-(Pyridinylphenyl)steroids—A new class of mixed-profile progesterone agonists/antagonists Pages 2753-2763 Jos Rewinkel, Mark Enthoven, Irene Golstein, Marcel van der Rijst, André Scholten, Martin van Tilborg, Dirk de Weys, Jeffry Wisse and Hans Hamersma

7.
Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer Pages 2764-2768 Srinivas K. Kumar, Indrajit Roy, Ravi K. Anchoori, Sarah Fazli, Anirban Maitra, Philip A. Beachy and Saeed R. Khan

8.
Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: Interaction with dopamine, serotonin, and norepinephrine transporters Pages 2769-2778 Manoj Mishra, Rohit Kolhatkar, Juan Zhen, Ingrid Parrington, Maarten E.A. Reith and Aloke K. Dutta

9.
Binding to human serum albumin of zidovudine (AZT) and novel AZT derivatives. Experimental and theoretical analyses Pages 2779-2790 Mario A. Quevedo, Sergio R. Ribone, Guillermo N. Moroni and Margarita C. Briñón

10.
Structure–activity relationship analysis of N-benzoylpyrazoles for elastase inhibitory activity: A simplified approach using atom pair descriptors Pages 2791-2802 Andrei I. Khlebnikov, Igor A. Schepetkin and Mark T. Quinn

11.
Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells Pages 2803-2810 Yukihiro Akao, Tomohiro itoh, Kenji Ohguchi, Munekazu Iinuma and Yoshinori Nozawa

12.
Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction Pages 2811-2818 Kenjiro Ikuta, Takeshi Mori, Tatsurhiro Yamamoto, Takuro Niidome, Hiroaki Shimokawa and Yoshiki Katayama

13.
Exploring the potential of 3′-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin Pages 2819-2828 Kalyan S. Ghosh, Joy Debnath, Palash Dutta, Bijaya K. Sahoo and Swagata Dasgupta

14.
Structure–activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties Pages 2829-2851 Ronald Palin, John K. Clark, Louise Evans, Andrea K. Houghton, Philip S. Jones, Alan Prosser, Grant Wishart and Kazuya Yoshiizumi

15.
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor Pages 2852-2869 Angela Stefanachi, Jose Manuel Brea, Maria Isabel Cadavid, Nuria B. Centeno, Cristina Esteve, Maria Isabel Loza, Ana Martinez, Rosa Nieto, Enrique Raviña, Ferran Sanz, Victor Segarra, Eddy Sotelo, Bernat Vidal and Angelo Carotti

16.
Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety Pages 2870-2885 Bettina Jung, Werner Englberger, Roland Fröhlich, Dirk Schepmann, Kirstin Lehmkuhl and Bernhard Wünsch

17.
Biocatalytic and semisynthetic optimization of the anti-invasive tobacco (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol Pages 2886-2893 Khalid A. El Sayed, Surat Laphookhieo, Hany N. Baraka, Muhammad Yousaf, Anne Hebert, Danielle Bagaley, Frederick A. Rainey, A. Muralidharan, Shibu Thomas and Girish V. Shah

18.
Synthesis and exploration of novel curcumin analogues as anti-malarial agents Pages 2894-2902 Satyendra Mishra, Krishanpal Karmodiya, Namita Surolia and Avadhesha Surolia

19.
A genetic algorithm optimized fuzzy neural network analysis of the affinity of inhibitors for HIV-1 protease Pages 2903-2911 Levente Fabry-Asztalos, Raˇzvan Andonie, Catharine J. Collar, Sarah Abdul-Wahid and Nicholas Salim

20.
New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana Pages 2912-2920 Jian-Guang Luo, Li Ma and Ling-Yi Kong

21.
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs Pages 2921-2931 Stephen Hanessian, Justyna A. Grzyb, Feride Cengelli and Lucienne Juillerat-Jeanneret

22.
Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages Pages 2932-2938 Soumyaditya Mula, Debashish Banerjee, Birija S. Patro, Sayanti Bhattacharya, Atanu Barik, Sandip K. Bandyopadhyay and Subrata Chattopadhyay

23.
1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae Pages 2939-2944 Mitsuki Naganuma, Masayuki Nishida, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida and Yoshiyuki Mizushina

24.
Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation Pages 2945-2954 Satoshi Obika, Hiroyasu Inohara, Yoshiyuki Hari and Takeshi Imanishi

25.
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety Pages 2955-2967 Robert Rönn, Anna Lampa, Shane D. Peterson, Thomas Gossas, Eva Åkerblom, U. Helena Danielson, Anders Karlén and Anja Sandström

26.
Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling Pages 2968-2973 Scott D. Bembenek, John M. Keith, Michael A. Letavic, Richard Apodaca, Ann J. Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L. Miller, Timothy W. Lovenberg and Nicholas I. Carruthers

27.
Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template Pages 2974-2983 John Spencer, John Gaffen, Eric Griffin, Elaine A. Harper, Ian D. Linney, Iain M. McDonald, Sonia P. Roberts, Mark E. Shaxted, Trushar Adatia and Alan Bashall

28.
Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies Pages 2984-2991 Welisson da Silva Ferreira, Leonardo Freire-de-Lima, Víctor Barbosa Saraiva, Frederico Alisson-Silva, Lucia Mendonça-Previato, José Osvaldo Previato, Aurea Echevarria and Marco Edilson Freire de Lima

29.
Synthesis and structure–affinity relationships of novel spirocyclic σ receptor ligands with furopyrazole structure Pages 2992-3001 Torsten Schläger, Dirk Schepmann, Ernst-Ulrich Würthwein and Bernhard Wünsch

30.
The 2α-(3-hydroxypropyl) group as an active motif in vitamin D3 analogues as agonists of the mutant vitamin D receptor (Arg274Leu) Pages 3002-3024 Shinobu Honzawa, Yasuhiro Yamamoto, Atsushi Yamashita, Takayuki Sugiura, Masaaki Kurihara, Midori A. Arai, Shigeaki Kato and Atsushi Kittaka

31.
Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate Pages 3025-3031 Ai Niitsu, Masanori Harada, Tohru Yamagaki and Kazuo Tachibana

32.
Role of benzimidazole (Bid) in the δ-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502) Pages 3032-3038 Severo Salvadori, Stella Fiorini, Claudio Trapella, Frank Porreca, Peg Davis, Yusuke Sasaki, Akihiro Ambo, Ewa D. Marczak, Lawrence H. Lazarus and Gianfranco Balboni

33.
Molecular modeling studies of N-substituted pyrrole derivatives—Potential HIV-1 gp41 inhibitors Pages 3039-3048 Cátia Teixeira, Florent Barbault, Joseph Rebehmed, Kun Liu, Lan Xie, Hong Lu, Shibo Jiang, BoTao Fan and François Maurel

34.
Docking analyses on human muscarinic receptors: Unveiling the subtypes peculiarities in agonists binding Pages 3049-3058 Giulio Vistoli, Alessandro Pedretti, Silvia Dei, Serena Scapecchi, Cristina Marconi and Maria Novella Romanelli

35.
Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems Pages 3059-3066 Nora Benaamane, Bellara Nedjar-Kolli, Yamina Bentarzi, Lamouri Hammal, Athina Geronikaki, Phaedra Eleftheriou and Alexey Lagunin

36.
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators) Pages 3067-3075 Qiang Lu, Joseph Peevey, Flora Jow, Michael M. Monaghan, Grace Mendoza, Howard Zhang, Jerome Wu, Callain Y. Kim, James Bicksler, Lynn Greenblatt, Stephen S. Lin, Wayne Childers and Mark R. Bowlby

37.
Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration Pages 3076-3083 Zhuo Chen, Xianyou Wang, Baoan Song, Hua Wang, Pinaki S. Bhadury, Kai Yan, Huiping Zhang, Song Yang, Linhong Jin, Deyu Hu, Wei Xue, Song Zeng and Jun Wang

38.
Effects of lipid constituents on membrane-permeabilizing activity of amphidinols Pages 3084-3090 Nagy Morsy, Toshihiro Houdai, Keiichi Konoki, Nobuaki Matsumori, Tohru Oishi and Michio Murata

39.
New anti-viral drugs for the treatment of the common cold Pages 3091-3107 Caterina Maugeri, Maria A. Alisi, Claudia Apicella, Luciano Cellai, Patrizia Dragone, Elena Fioravanzo, Saverio Florio, Guido Furlotti, Giorgina Mangano, Rosella Ombrato, Renzo Luisi, Raffaello Pompei, Vito Rincicotti, Vincenzo Russo, Marco Vitiello and Nicola Cazzolla

40.
Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines Pages 3108-3117 Yoshitomo Suhara, Yoshihisa Hirota, Kimie Nakagawa, Maya Kamao, Naoko Tsugawa and Toshio Okano

41.
N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Pages 3118-3124 Lidia Matesic, Julie M. Locke, John B. Bremner, Stephen G. Pyne, Danielle Skropeta, Marie Ranson and Kara L. Vine

42.
Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active Factor Xa inhibitors Pages 3125-3140 Yasuhiro Imaeda, Tetsuji Kawamoto, Mamoru Tobisu, Noriko Konishi, Katsuhiko Hiroe, Masaki Kawamura, Toshimasa Tanaka and Keiji Kubo

43.
Structure–activity relationship of uniconazole, a potent inhibitor of ABA 8′-hydroxylase, with a focus on hydrophilic functional groups and conformation Pages 3141-3152 Yasushi Todoroki, Kyotaro Kobayashi, Hidetaka Yoneyama, Saori Hiramatsu, Mei-Hong Jin, Bunta Watanabe, Masaharu Mizutani and Nobuhiro Hirai

44.
Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives Pages 3153-3162 Chih-Hua Tseng, Yeh-Long Chen, Pei-Jung Lu, Chia-Ning Yang and Cherng-Chyi Tzeng

45.
Synthesis of insecticidal fluorinated anthranilic diamides Pages 3163-3170 David A. Clark, George P. Lahm, Ben K. Smith, James D. Barry and Don G. Clagg

46.
Core-modified porphyrins. Part 6: Effects of lipophilicity and core structures on physicochemical and biological properties in vitro Pages 3171-3183 Ethel J. Ngen, Thalia S. Daniels, Rajesh S. Murthy, Michael R. Detty and Youngjae You

47.
Structure–reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets Pages 3184-3190 Paola R. Campodónico and Renato Contreras

48.
Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT Pages 3191-3208 Michael W. Easson, Frank R. Fronczek, Timothy J. Jensen and M. Graça H. Vicente

49.
Synthesis and cytotoxic activity of diosgenyl saponin analogues Pages 3209-3217 Matthew J. Kaskiw, Mary Lynn Tassotto, John Th’ng and Zi-Hua Jiang

50.
Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors Pages 3218-3223 Zhongze Ma, Wei Xu, Lee-Yuan Liu-Chen and David Y.W. Lee

51.
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain Pages 3224-3232 Carlo Farina, Stefania Gagliardi, Carla Ghelardini, Marisa Martinelli, Monica Norcini, Carlo Parini, Paola Petrillo and Silvano Ronzoni

52.
Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans Pages 3233-3244 Sebastian A. Andujar, Biagina Migliore de Angel, Jaime E. Charris, Anita Israel, Heberto Suárez-Roca, Simon E. López, Maria R. Garrido, Elvia Victoria Cabrera, Gonzalo Visbal, Cecire Rosales, Fernando D. Suvire, Ricardo D. Enriz and Jorge E. Angel-Guío

53.
Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors Pages 3245-3254 Urmi Dhagat, Satoshi Endo, Akira Hara and Ossama El-Kabbani

54.
Novel nitroheterocyclic hypoxic markers for solid tumor: Synthesis and biological evaluation Pages 3255-3260 Weiping Zhu, Min Dai, Yufang Xu and Xuhong Qian

55.
Synthesis, analgesic, anti-inflammatory, and antimicrobial activity of some novel pyrimido[4,5-b]quinolin-4-ones Pages 3261-3273 Abdel-Rahman B.A. El-Gazzar, Mervat M. El-Enany and Mahmoud N. Mahmoud

56.
Synthesis of naphtho[2,3-a]phenoxazinium chlorides: Structure–activity relationships of these heterocycles and benzo[a]phenoxazinium chlorides as new antimicrobials Pages 3274-3282 Vânia H.J. Frade, Maria J. Sousa, João C.V.P. Moura and M. Sameiro T. Gonçalves

57.
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase Pages 3283-3290 Sergio H. Szajnman, Guadalupe E. Garcı´a Liñares, Zhu-Hong Li, Cuiying Jiang, Melina Galizzi, Esteban J. Bontempi, Marcela Ferella, Silvia N.J. Moreno, Roberto Docampo and Juan B. Rodriguez

58.
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation Pages 3291-3301 Christine M. Wright, Raj J. Chovatiya, Nora E. Jameson, David M. Turner, Guangyu Zhu, Stefan Werner, Donna M. Huryn, James M. Pipas, Billy W. Day, Peter Wipf and Jeffrey L. Brodsky

59.
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: Synthesis, cyclooxygenase inhibition, and nitric oxide release studies Pages 3302-3308 Khaled R.A. Abdellatif, Morshed Alam Chowdhury, Ying Dong, Qiao-Hong Chen and Edward E. Knaus

60.
Synthesis and structure–activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists Pages 3309-3320 Itsuro Shimada, Kyoichi Maeno, Yutaka Kondoh, Hidetaka Kaku, Keizo Sugasawa, Yasuharu Kimura, Ken-ichi Hatanaka, Yuki Naitou, Fumikazu Wanibuchi, Shuichi Sakamoto and Shin-ichi Tsukamoto

61.
Synthesis and structure–activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists Pages 3321-3341 Lan Shen, Yan Zhang, Aihua Wang, Ellen Sieber-McMaster, Xiaoli Chen, Patricia Pelton, June Z. Xu, Maria Yang, Peifang Zhu, Lubing Zhou, Michael Reuman, Zhiyong Hu, Ronald Russell, Alan C. Gibbs, Hamish Ross, Keith Demarest, William V. Murray and Gee-Hong Kuo

62.
Oligo(tyrosine sulfate)s as heparin pentasaccharide mimic: Evaluation by surface noncovalent affinity mass spectrometry Pages 3342-3351 Miyuki Yamaguchi, Tsukasa Ohmori, Yoichi Sakata and Masaaki Ueki

63.
Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts Pages 3352-3360 Lalji K. Gediya, Aashvini Belosay, Aakanksha Khandelwal, Puranik Purushottamachar and Vincent C.O. Njar

64.
Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates Pages 3361-3371 Timothy Haemers, Jochen Wiesner, Dirk Gießmann, Thomas Verbrugghen, Ulrik Hillaert, Regina Ortmann, Hassan Jomaa, Andreas Link, Martin Schlitzer and Serge Van Calenbergh

65.
Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the α-aminoadipate pathway Pages 3372-3376 Takashi Yamamoto and Tadashi Eguchi

66.
Synthetic derivatives of the α- and β-amyrin triterpenes and their antinociceptive properties Pages 3377-3386 Cristian Soldi, Moacir Geraldo Pizzolatti, Ana Paula Luiz, Rodrigo Marcon, Flavia Carla Meotti, Letícia Adelia Mioto and Adair R.S. Santos

67.
Structure and estrogenic activity of new lignans from Iryanthera lancifolia Pages 3387-3394 Dulce Mesa-Siverio, Rubén P. Machín, Ana Estévez-Braun, Ángel. G. Ravelo and Olga Lock

68.
QSAR modeling of the rodent carcinogenicity of nitrocompounds Pages 3395-3407 Aliuska Morales Helguera, M. Natália D.S. Cordeiro, Miguel Ángel Cabrera Pérez, Robert D. Combes and Maykel Pérez González

69.
Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid Pages 3408-3418 Murugesan Dinakaran, Palaniappan Senthilkumar, Perumal Yogeeswari, Arnab China, Valakunja Nagaraja and Dharmarajan Sriram

70.
Deoxygenated phosphorothioate inositol phosphate analogs: Synthesis, phosphatase stability, and binding affinity Pages 3419-3427 Xiaodan Liu, Emily C. Moody, Stephen S. Hecht and Shana J. Sturla

71.
Synthesis and structure–activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem Pages 3428-3437 Andrea Cappelli, Germano Giuliani, Salvatore Valenti, Maurizio Anzini, Salvatore Vomero, Gianluca Giorgi, Cristiana Sogliano, Elisabetta Maciocco, Giovanni Biggio and Alessandra Concas

72.
A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol Pages 3438-3444 Danyang Liu, Durk Dijkstra, Jan B. de Vries and Håkan V. Wikström

73.
Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells Pages 3445-3455 Ioannis K. Kostakis, Nicole Pouli, Panagiotis Marakos, Olga Ch. Kousidou, Andreas Roussidis, George N. Tzanakakis and Nikos K. Karamanos

74.
3D-QSAR CoMFA studies on bis-coumarine analogues as urease inhibitors: A strategic design in anti-urease agents Pages 3456-3461 Zaheer-ul-Haq, M. Arif Lodhi, Sarfraz Ahmad Nawaz, Sajid Iqbal, Khalid Mohammed Khan, Bernd M. Rode, Atta-ur-Rahman and M. Iqbal Choudhary

75.
Corrigendum to “Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2′O)-methyltransferase” [Bioorg. Med. Chem. 15 (2007) 7795–7802] Page 3462 Victor B. Luzhkov, Barbara Selisko, Anneli Nordqvist, Frédéric Peyrane, Etienne Decroly, Karine Alvarez, Anders Karlen, Bruno Canard and Johan Åqvist

Biochemical Pharmacology :Vol 75, Issue 8

2008-04-28T09:33:00.000+01:00

Commentary

2.
Anti-inflammatory interventions of NF-κB signaling: Potential applications and risks Pages 1567-1579 Senftleben Uwe

Antibiotics and Chemotherapeutics

3.
Accumulation of the antimalarial microtubule inhibitors trifluralin and vinblastine by Plasmodium falciparum Pages 1580-1587 Julie Ann Naughton, Ruth Hughes, Patrick Bray and Angus Bell

4.
Structure–activity relationship for adenosine kinase from Mycobacterium tuberculosis: II. Modifications to the ribofuranosyl moiety Pages 1588-1600 Mary C. Long, Sue C. Shaddix, Omar Moukha-Chafiq, Joseph A. Maddry, Lisa Nagy and William B. Parker

5.
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus Pages 1601-1609 Chi-Yuan Chou, Chia-Hui Chien, Yu-San Han, Mojca Trstenjak Prebanda, Hsing-Pang Hsieh, Boris Turk, Gu-Gang Chang and Xin Chen

6.
Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines Pages 1610-1615 Matthew D. Lynx, Bae-Kwang Kang and Edward E. McKee

7.
Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances Pages 1616-1622 Hideyuki Terazono, Ahmed Hamdan, Naoya Matsunaga, Naoto Hayasaka, Hiroaki Kaji, Takashi Egawa, Kazutaka Makino, Yasufumi Shigeyoshi, Satoru Koyanagi and Shigehiro Ohdo

Cardiovascular Pharmacology

8.
Transactivation of epidermal growth factor receptor in vascular and renal systems in rats with experimental hyperleptinemia: Role in leptin-induced hypertension Pages 1623-1638 Anna Jamroz-Wiśniewska, Grażyna Wójcicka, Ewelina Łowicka, Marta Książek and Jerzy Bełtowski

9.
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis Pages 1639-1648 Azusa Takahashi, Eriko Komiya, Hideki Kakutani, Takeshi Yoshida, Makiko Fujii, Yasuhiko Horiguchi, Hiroyuki Mizuguchi, Yasuo Tsutsumi, Shin-ichi Tsunoda, Naoya Koizumi, Katsuhiro Isoda, Kiyohito Yagi, Yoshiteru Watanabe and Masuo Kondoh

10.
Insulin therapy restores impaired function and expression of P-glycoprotein in blood–brain barrier of experimental diabetes Pages 1649-1658 Haiyan Liu, Xiaodong Liu, Lee Jia, Yuchun Liu, Huiwen Yang, Guangji Wang and Lin Xie

Pharmacokinetics and Drug Metabolism

11.
Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter Pages 1659-1669 Isabelle J. Létourneau, Akio Nakajima, Roger G. Deeley and Susan P.C. Cole

12.
Quercetin pretreatment increases the bioavailability of pioglitazone in rats: Involvement of CYP3A inhibition Pages 1670-1676 Sudhir N. Umathe, Pankaj V. Dixit, Vijendra kumar, Kuldeep U. Bansod and Manish M. Wanjari

13.
Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy Pages 1677-1687 Leslie J. Dickmann, Suzanne Tay, Tauri D. Senn, Huixia Zhang, Anthony Visone, Jashvant D. Unadkat, Mary F. Hebert and Nina Isoherranen

Mutation Research Letters: Vol 348, Issue 4

2008-03-31T09:17:00.000+01:00

2.
Genotoxicity assay of chloral hydrate and chloropicrinePages 147-152S. Giller, F. Le Curieux, L. Gauthier, F. Erb and D. Marzin
Abstract Abstract + References PDF (354 K)
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3.
Advantages and limitations of using fluorescence in situ hybridization for the detection of aneuploidy in interphase human cellsPages 153-162David A. Eastmond, Maik Schuler and D. S. Rupa
Abstract Abstract + References PDF (724 K)
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4.
Synergistic action of N-nitrosodialkylamines and near-UV in the induction of chromosome aberrations in Chinese hamster lung fibroblasts in vitroPages 163-168Yasuhiro Yamashita, Nabuyoshi Sumi, Sakae Arimoto and Hikoya Hayatsu
Abstract Abstract + References PDF (337 K)
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5.
DNA damaging and cell proliferative activity of 1-methyl-1-nitrosourea in rat glandular stomach mucosaPages 169-173Chie Furihata, Emi Ikui and Taijiro Matsushima
Abstract Abstract + References PDF (307 K)
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6.
Effects of indomethacin and arachidonic acid on sister chromatid exchange induction by styrene and styrene-7,8-oxidePages 175-181Se-Hoon Lee and Hannu Norppa
Abstract Abstract + References PDF (464 K)
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7.
PM2 DNA damage induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)Pages 183-186Juha M. T. Hyttinen and Kristian Jansson
Abstract Abstract + References PDF (222 K)
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8.
Persistence of increased levels of ribosomal gene activity in CHO-K1 cells treated in vitro with demethylating agentsPages 187-192Paola Giancotti, Claudio Grappelli, Italo Poggesi, Marco Abatecola, Adriana de Capoa, Renata Cozzi and Paolo Perticone,
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9.
Mutagenic effects at hprt locus and in minisatellite sequences induced in V79 cells by treatments with UV and methyl-nitro-nitroso guanidinePages 193-199S. Ogheri, C. Rampazzo and L. Celotti
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10.
Enhanced reactivation of nitrous acid treated adenovirus is not associated with enhanced mutagenesis in pretreated with heavy metals HeLa cellsPages 201-204S. M. Piperakis
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