Regulatory Toxicology and Pharmacology: Vol 50, Issue 3

REGULAR ARTICLES

2.
Effects of MTBE on the reported incidence of Leydig cell tumors in Sprague–Dawley rats: Range of possible Poly-3 results Pages 273-284 Julie E. Goodman, David Gaylor, Leslie A. Beyer, Lorenz R. Rhomberg and Barbara D. Beck

3.
An evaluation of the genotoxicity of the antitussive drug Dextromethorphan Pages 285-293 Marilyn J. Aardema, Steven H. Robison, David Gatehouse and Gail Johnston

4.
Preclinical safety evaluation of IFNα2a-NGR Pages 294-302 Jieru Meng, Zhen Yan, Yongjie Wu, Mingtang Gao, Wenguang Li, Fei Gao, Hongxing Wang, Wei Han and Yingqi Zhang

5.
Safety assessment of 2-ethyl-3,(5 or 6) dimethylpyrazine as a food ingredient Pages 303-312 George A. Burdock and Ioana G. Carabin

6.
Defining maximum levels of higher alcohols in alcoholic beverages and surrogate alcohol products Pages 313-321 Dirk W. Lachenmeier, Simone Haupt and Katja Schulz

7.
Mutagenicity assessment of acrylate and methacrylate compounds and implications for regulatory toxicology requirements Pages 322-335 F.R. Johannsen, Barbara Vogt, Maureen Waite and Randy Deskin

8.
Improving the quality of risk assessments in Canada using a principle-based approach Pages 336-344 P.M. Forristal, D.L. Wilke and L.S. McCarty

9.
A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development Pages 345-352 Sally Robinson, Jean-Luc Delongeas, Elizabeth Donald, David Dreher, Matthias Festag, Sophie Kervyn, Ann Lampo, Kamil Nahas, Vicente Nogues, Deborah Ockert, Kirsty Quinn, Sally Old, Nigel Pickersgill, Kev Somers, Claudia Stark, Peter Stei, Lynne Waterson and Kathryn Chapman

10.
In vitro activity of dermaseptin S4 derivatives against genital infections pathogens Pages 353-358 Amira Zairi, Frédéric Tangy, Souhir Saadi and Khaled Hani

11.
Could charcoal filtration of cigarette smoke reduce smoking-induced disease? A review of the literature Pages 359-365 Christopher R.E. Coggins and Charles L. Gaworski

12.
Modeling of DR CALUX® bioassay response to screen PCDDs, PCDFs, and dioxin-like PCBs in farm milk from dairy herds Pages 366-375 Igor Fochi, Gianfranco Brambilla, Stefania P. De Filippis, Silvia De Luca, Gianfranco Diletti, Annarita Fulgenzi, Pasquale Gallo, Nicola Iacovella, Giampiero Scortichini, Luigi Serpe, Floriana Vinci and Alessandro di Domenico

13.
Risk assessment for the amino acids taurine, l-glutamine and l-arginine Pages 376-399 Andrew Shao and John N. Hathcock

14.
Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps Pages 400-411 George Loizou, Martin Spendiff, Hugh A. Barton, Jos Bessems, Frédéric Y. Bois, Michel Bouvier d’Yvoire, Harrie Buist, Harvey J. Clewell III, Bette Meek, Ursula Gundert-Remy, Gerhard Goerlitz and Walter Schmitt

15.
Towards more efficient testing strategies—Analyzing the efficiency of toxicity data requirements in relation to the criteria for classification and labelling Pages 412-419 Anna Nordberg, Christina Rudén and Sven Ove Hansson

16.
Human health risk assessments for three neuropharmaceutical compounds in surface waters Pages 420-427 Joel P. Bercu, Neil J. Parke, Janice M. Fiori and Roger D. Meyerhoff

LETTERS TO THE EDITOR

17.
MtBE and cancer in animals: Statistical issues with poly-3 survival adjustments for lifetime studies Pages 428-429 Grace E. Kissling, Christopher J. Portier and James Huff

18.
Letter to the Editor Page 430 Barbara Beck