Bioorganic and Medicinal Chemistry: Vol 16, Issue 6

1.
Editorial board Page IFC


2.
Graphical contents list Pages 2707-2725


3.
A comparative density-functional study of the reaction mechanism of the O2-dependent coproporphyrinogen III oxidase Pages 2726-2733 Pedro J. Silva and Maria João Ramos


4.
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases Pages 2734-2740 Yasuhiro Minami, Chinami Kuriyama, Kyoko Ikeda, Atsushi Kato, Kenji Takebayashi, Isao Adachi, George W.J. Fleet, Aikkarach Kettawan, Tadashi Okamoto and Naoki Asano


5.
A new generation of adenosine receptor antagonists: From di- to trisubstituted aminopyrimidines Pages 2741-2752 Jacobus P.D. van Veldhoven, Lisa C.W. Chang, Jacobien K. von Frijtag Drabbe Künzel, Thea Mulder-Krieger, Regina Struensee-Link, Margot W. Beukers, Johannes Brussee and Adriaan P. IJzerman


6.
11-(Pyridinylphenyl)steroids—A new class of mixed-profile progesterone agonists/antagonists Pages 2753-2763 Jos Rewinkel, Mark Enthoven, Irene Golstein, Marcel van der Rijst, André Scholten, Martin van Tilborg, Dirk de Weys, Jeffry Wisse and Hans Hamersma


7.
Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer Pages 2764-2768 Srinivas K. Kumar, Indrajit Roy, Ravi K. Anchoori, Sarah Fazli, Anirban Maitra, Philip A. Beachy and Saeed R. Khan


8.
Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: Interaction with dopamine, serotonin, and norepinephrine transporters Pages 2769-2778 Manoj Mishra, Rohit Kolhatkar, Juan Zhen, Ingrid Parrington, Maarten E.A. Reith and Aloke K. Dutta


9.
Binding to human serum albumin of zidovudine (AZT) and novel AZT derivatives. Experimental and theoretical analyses Pages 2779-2790 Mario A. Quevedo, Sergio R. Ribone, Guillermo N. Moroni and Margarita C. Briñón


10.
Structure–activity relationship analysis of N-benzoylpyrazoles for elastase inhibitory activity: A simplified approach using atom pair descriptors Pages 2791-2802 Andrei I. Khlebnikov, Igor A. Schepetkin and Mark T. Quinn


11.
Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells Pages 2803-2810 Yukihiro Akao, Tomohiro itoh, Kenji Ohguchi, Munekazu Iinuma and Yoshinori Nozawa


12.
Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction Pages 2811-2818 Kenjiro Ikuta, Takeshi Mori, Tatsurhiro Yamamoto, Takuro Niidome, Hiroaki Shimokawa and Yoshiki Katayama


13.
Exploring the potential of 3′-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin Pages 2819-2828 Kalyan S. Ghosh, Joy Debnath, Palash Dutta, Bijaya K. Sahoo and Swagata Dasgupta


14.
Structure–activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties Pages 2829-2851 Ronald Palin, John K. Clark, Louise Evans, Andrea K. Houghton, Philip S. Jones, Alan Prosser, Grant Wishart and Kazuya Yoshiizumi


15.
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor Pages 2852-2869 Angela Stefanachi, Jose Manuel Brea, Maria Isabel Cadavid, Nuria B. Centeno, Cristina Esteve, Maria Isabel Loza, Ana Martinez, Rosa Nieto, Enrique Raviña, Ferran Sanz, Victor Segarra, Eddy Sotelo, Bernat Vidal and Angelo Carotti


16.
Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety Pages 2870-2885 Bettina Jung, Werner Englberger, Roland Fröhlich, Dirk Schepmann, Kirstin Lehmkuhl and Bernhard Wünsch


17.
Biocatalytic and semisynthetic optimization of the anti-invasive tobacco (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol Pages 2886-2893 Khalid A. El Sayed, Surat Laphookhieo, Hany N. Baraka, Muhammad Yousaf, Anne Hebert, Danielle Bagaley, Frederick A. Rainey, A. Muralidharan, Shibu Thomas and Girish V. Shah


18.
Synthesis and exploration of novel curcumin analogues as anti-malarial agents Pages 2894-2902 Satyendra Mishra, Krishanpal Karmodiya, Namita Surolia and Avadhesha Surolia


19.
A genetic algorithm optimized fuzzy neural network analysis of the affinity of inhibitors for HIV-1 protease Pages 2903-2911 Levente Fabry-Asztalos, Raˇzvan Andonie, Catharine J. Collar, Sarah Abdul-Wahid and Nicholas Salim


20.
New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana Pages 2912-2920 Jian-Guang Luo, Li Ma and Ling-Yi Kong


21.
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs Pages 2921-2931 Stephen Hanessian, Justyna A. Grzyb, Feride Cengelli and Lucienne Juillerat-Jeanneret


22.
Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages Pages 2932-2938 Soumyaditya Mula, Debashish Banerjee, Birija S. Patro, Sayanti Bhattacharya, Atanu Barik, Sandip K. Bandyopadhyay and Subrata Chattopadhyay


23.
1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae Pages 2939-2944 Mitsuki Naganuma, Masayuki Nishida, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida and Yoshiyuki Mizushina


24.
Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation Pages 2945-2954 Satoshi Obika, Hiroyasu Inohara, Yoshiyuki Hari and Takeshi Imanishi


25.
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety Pages 2955-2967 Robert Rönn, Anna Lampa, Shane D. Peterson, Thomas Gossas, Eva Åkerblom, U. Helena Danielson, Anders Karlén and Anja Sandström


26.
Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling Pages 2968-2973 Scott D. Bembenek, John M. Keith, Michael A. Letavic, Richard Apodaca, Ann J. Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L. Miller, Timothy W. Lovenberg and Nicholas I. Carruthers


27.
Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template Pages 2974-2983 John Spencer, John Gaffen, Eric Griffin, Elaine A. Harper, Ian D. Linney, Iain M. McDonald, Sonia P. Roberts, Mark E. Shaxted, Trushar Adatia and Alan Bashall


28.
Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies Pages 2984-2991 Welisson da Silva Ferreira, Leonardo Freire-de-Lima, Víctor Barbosa Saraiva, Frederico Alisson-Silva, Lucia Mendonça-Previato, José Osvaldo Previato, Aurea Echevarria and Marco Edilson Freire de Lima


29.
Synthesis and structure–affinity relationships of novel spirocyclic σ receptor ligands with furopyrazole structure Pages 2992-3001 Torsten Schläger, Dirk Schepmann, Ernst-Ulrich Würthwein and Bernhard Wünsch


30.
The 2α-(3-hydroxypropyl) group as an active motif in vitamin D3 analogues as agonists of the mutant vitamin D receptor (Arg274Leu) Pages 3002-3024 Shinobu Honzawa, Yasuhiro Yamamoto, Atsushi Yamashita, Takayuki Sugiura, Masaaki Kurihara, Midori A. Arai, Shigeaki Kato and Atsushi Kittaka


31.
Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate Pages 3025-3031 Ai Niitsu, Masanori Harada, Tohru Yamagaki and Kazuo Tachibana


32.
Role of benzimidazole (Bid) in the δ-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502) Pages 3032-3038 Severo Salvadori, Stella Fiorini, Claudio Trapella, Frank Porreca, Peg Davis, Yusuke Sasaki, Akihiro Ambo, Ewa D. Marczak, Lawrence H. Lazarus and Gianfranco Balboni


33.
Molecular modeling studies of N-substituted pyrrole derivatives—Potential HIV-1 gp41 inhibitors Pages 3039-3048 Cátia Teixeira, Florent Barbault, Joseph Rebehmed, Kun Liu, Lan Xie, Hong Lu, Shibo Jiang, BoTao Fan and François Maurel


34.
Docking analyses on human muscarinic receptors: Unveiling the subtypes peculiarities in agonists binding Pages 3049-3058 Giulio Vistoli, Alessandro Pedretti, Silvia Dei, Serena Scapecchi, Cristina Marconi and Maria Novella Romanelli


35.
Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems Pages 3059-3066 Nora Benaamane, Bellara Nedjar-Kolli, Yamina Bentarzi, Lamouri Hammal, Athina Geronikaki, Phaedra Eleftheriou and Alexey Lagunin


36.
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators) Pages 3067-3075 Qiang Lu, Joseph Peevey, Flora Jow, Michael M. Monaghan, Grace Mendoza, Howard Zhang, Jerome Wu, Callain Y. Kim, James Bicksler, Lynn Greenblatt, Stephen S. Lin, Wayne Childers and Mark R. Bowlby


37.
Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration Pages 3076-3083 Zhuo Chen, Xianyou Wang, Baoan Song, Hua Wang, Pinaki S. Bhadury, Kai Yan, Huiping Zhang, Song Yang, Linhong Jin, Deyu Hu, Wei Xue, Song Zeng and Jun Wang


38.
Effects of lipid constituents on membrane-permeabilizing activity of amphidinols Pages 3084-3090 Nagy Morsy, Toshihiro Houdai, Keiichi Konoki, Nobuaki Matsumori, Tohru Oishi and Michio Murata


39.
New anti-viral drugs for the treatment of the common cold Pages 3091-3107 Caterina Maugeri, Maria A. Alisi, Claudia Apicella, Luciano Cellai, Patrizia Dragone, Elena Fioravanzo, Saverio Florio, Guido Furlotti, Giorgina Mangano, Rosella Ombrato, Renzo Luisi, Raffaello Pompei, Vito Rincicotti, Vincenzo Russo, Marco Vitiello and Nicola Cazzolla


40.
Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines Pages 3108-3117 Yoshitomo Suhara, Yoshihisa Hirota, Kimie Nakagawa, Maya Kamao, Naoko Tsugawa and Toshio Okano


41.
N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Pages 3118-3124 Lidia Matesic, Julie M. Locke, John B. Bremner, Stephen G. Pyne, Danielle Skropeta, Marie Ranson and Kara L. Vine


42.
Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active Factor Xa inhibitors Pages 3125-3140 Yasuhiro Imaeda, Tetsuji Kawamoto, Mamoru Tobisu, Noriko Konishi, Katsuhiko Hiroe, Masaki Kawamura, Toshimasa Tanaka and Keiji Kubo


43.
Structure–activity relationship of uniconazole, a potent inhibitor of ABA 8′-hydroxylase, with a focus on hydrophilic functional groups and conformation Pages 3141-3152 Yasushi Todoroki, Kyotaro Kobayashi, Hidetaka Yoneyama, Saori Hiramatsu, Mei-Hong Jin, Bunta Watanabe, Masaharu Mizutani and Nobuhiro Hirai


44.
Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives Pages 3153-3162 Chih-Hua Tseng, Yeh-Long Chen, Pei-Jung Lu, Chia-Ning Yang and Cherng-Chyi Tzeng


45.
Synthesis of insecticidal fluorinated anthranilic diamides Pages 3163-3170 David A. Clark, George P. Lahm, Ben K. Smith, James D. Barry and Don G. Clagg


46.
Core-modified porphyrins. Part 6: Effects of lipophilicity and core structures on physicochemical and biological properties in vitro Pages 3171-3183 Ethel J. Ngen, Thalia S. Daniels, Rajesh S. Murthy, Michael R. Detty and Youngjae You


47.
Structure–reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets Pages 3184-3190 Paola R. Campodónico and Renato Contreras


48.
Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT Pages 3191-3208 Michael W. Easson, Frank R. Fronczek, Timothy J. Jensen and M. Graça H. Vicente


49.
Synthesis and cytotoxic activity of diosgenyl saponin analogues Pages 3209-3217 Matthew J. Kaskiw, Mary Lynn Tassotto, John Th’ng and Zi-Hua Jiang


50.
Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors Pages 3218-3223 Zhongze Ma, Wei Xu, Lee-Yuan Liu-Chen and David Y.W. Lee


51.
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain Pages 3224-3232 Carlo Farina, Stefania Gagliardi, Carla Ghelardini, Marisa Martinelli, Monica Norcini, Carlo Parini, Paola Petrillo and Silvano Ronzoni


52.
Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans Pages 3233-3244 Sebastian A. Andujar, Biagina Migliore de Angel, Jaime E. Charris, Anita Israel, Heberto Suárez-Roca, Simon E. López, Maria R. Garrido, Elvia Victoria Cabrera, Gonzalo Visbal, Cecire Rosales, Fernando D. Suvire, Ricardo D. Enriz and Jorge E. Angel-Guío


53.
Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors Pages 3245-3254 Urmi Dhagat, Satoshi Endo, Akira Hara and Ossama El-Kabbani


54.
Novel nitroheterocyclic hypoxic markers for solid tumor: Synthesis and biological evaluation Pages 3255-3260 Weiping Zhu, Min Dai, Yufang Xu and Xuhong Qian


55.
Synthesis, analgesic, anti-inflammatory, and antimicrobial activity of some novel pyrimido[4,5-b]quinolin-4-ones Pages 3261-3273 Abdel-Rahman B.A. El-Gazzar, Mervat M. El-Enany and Mahmoud N. Mahmoud


56.
Synthesis of naphtho[2,3-a]phenoxazinium chlorides: Structure–activity relationships of these heterocycles and benzo[a]phenoxazinium chlorides as new antimicrobials Pages 3274-3282 Vânia H.J. Frade, Maria J. Sousa, João C.V.P. Moura and M. Sameiro T. Gonçalves


57.
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase Pages 3283-3290 Sergio H. Szajnman, Guadalupe E. Garcı´a Liñares, Zhu-Hong Li, Cuiying Jiang, Melina Galizzi, Esteban J. Bontempi, Marcela Ferella, Silvia N.J. Moreno, Roberto Docampo and Juan B. Rodriguez


58.
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation Pages 3291-3301 Christine M. Wright, Raj J. Chovatiya, Nora E. Jameson, David M. Turner, Guangyu Zhu, Stefan Werner, Donna M. Huryn, James M. Pipas, Billy W. Day, Peter Wipf and Jeffrey L. Brodsky


59.
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: Synthesis, cyclooxygenase inhibition, and nitric oxide release studies Pages 3302-3308 Khaled R.A. Abdellatif, Morshed Alam Chowdhury, Ying Dong, Qiao-Hong Chen and Edward E. Knaus


60.
Synthesis and structure–activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists Pages 3309-3320 Itsuro Shimada, Kyoichi Maeno, Yutaka Kondoh, Hidetaka Kaku, Keizo Sugasawa, Yasuharu Kimura, Ken-ichi Hatanaka, Yuki Naitou, Fumikazu Wanibuchi, Shuichi Sakamoto and Shin-ichi Tsukamoto


61.
Synthesis and structure–activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists Pages 3321-3341 Lan Shen, Yan Zhang, Aihua Wang, Ellen Sieber-McMaster, Xiaoli Chen, Patricia Pelton, June Z. Xu, Maria Yang, Peifang Zhu, Lubing Zhou, Michael Reuman, Zhiyong Hu, Ronald Russell, Alan C. Gibbs, Hamish Ross, Keith Demarest, William V. Murray and Gee-Hong Kuo


62.
Oligo(tyrosine sulfate)s as heparin pentasaccharide mimic: Evaluation by surface noncovalent affinity mass spectrometry Pages 3342-3351 Miyuki Yamaguchi, Tsukasa Ohmori, Yoichi Sakata and Masaaki Ueki


63.
Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts Pages 3352-3360 Lalji K. Gediya, Aashvini Belosay, Aakanksha Khandelwal, Puranik Purushottamachar and Vincent C.O. Njar


64.
Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates Pages 3361-3371 Timothy Haemers, Jochen Wiesner, Dirk Gießmann, Thomas Verbrugghen, Ulrik Hillaert, Regina Ortmann, Hassan Jomaa, Andreas Link, Martin Schlitzer and Serge Van Calenbergh


65.
Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the α-aminoadipate pathway Pages 3372-3376 Takashi Yamamoto and Tadashi Eguchi


66.
Synthetic derivatives of the α- and β-amyrin triterpenes and their antinociceptive properties Pages 3377-3386 Cristian Soldi, Moacir Geraldo Pizzolatti, Ana Paula Luiz, Rodrigo Marcon, Flavia Carla Meotti, Letícia Adelia Mioto and Adair R.S. Santos


67.
Structure and estrogenic activity of new lignans from Iryanthera lancifolia Pages 3387-3394 Dulce Mesa-Siverio, Rubén P. Machín, Ana Estévez-Braun, Ángel. G. Ravelo and Olga Lock


68.
QSAR modeling of the rodent carcinogenicity of nitrocompounds Pages 3395-3407 Aliuska Morales Helguera, M. Natália D.S. Cordeiro, Miguel Ángel Cabrera Pérez, Robert D. Combes and Maykel Pérez González


69.
Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid Pages 3408-3418 Murugesan Dinakaran, Palaniappan Senthilkumar, Perumal Yogeeswari, Arnab China, Valakunja Nagaraja and Dharmarajan Sriram


70.
Deoxygenated phosphorothioate inositol phosphate analogs: Synthesis, phosphatase stability, and binding affinity Pages 3419-3427 Xiaodan Liu, Emily C. Moody, Stephen S. Hecht and Shana J. Sturla


71.
Synthesis and structure–activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem Pages 3428-3437 Andrea Cappelli, Germano Giuliani, Salvatore Valenti, Maurizio Anzini, Salvatore Vomero, Gianluca Giorgi, Cristiana Sogliano, Elisabetta Maciocco, Giovanni Biggio and Alessandra Concas


72.
A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol Pages 3438-3444 Danyang Liu, Durk Dijkstra, Jan B. de Vries and Håkan V. Wikström


73.
Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells Pages 3445-3455 Ioannis K. Kostakis, Nicole Pouli, Panagiotis Marakos, Olga Ch. Kousidou, Andreas Roussidis, George N. Tzanakakis and Nikos K. Karamanos


74.
3D-QSAR CoMFA studies on bis-coumarine analogues as urease inhibitors: A strategic design in anti-urease agents Pages 3456-3461 Zaheer-ul-Haq, M. Arif Lodhi, Sarfraz Ahmad Nawaz, Sajid Iqbal, Khalid Mohammed Khan, Bernd M. Rode, Atta-ur-Rahman and M. Iqbal Choudhary


75.
Corrigendum to “Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2′O)-methyltransferase” [Bioorg. Med. Chem. 15 (2007) 7795–7802] Page 3462 Victor B. Luzhkov, Barbara Selisko, Anneli Nordqvist, Frédéric Peyrane, Etienne Decroly, Karine Alvarez, Anders Karlen, Bruno Canard and Johan Åqvist