Bioorganic and Medicinal Chemistry Letters: Vol 18, Issue 7

2.
Graphical contents list Pages 2231-2245


3.
Rhodamine-based fluorogenic probe for imaging biological thiol Pages 2246-2249 Aya Shibata, Kazuhiro Furukawa, Hiroshi Abe, Satoshi Tsuneda and Yoshihiro Ito


4.
Discovery of novel PRL-3 inhibitors based on the structure-based virtual screening Pages 2250-2255 Hwangseo Park, Suk-Kyeong Jung, Dae Gwin Jeong, Seong Eon Ryu and Seung Jun Kim


5.
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824 Pages 2256-2262 Xiaojin Li, Ujjini H. Manjunatha, Michael B. Goodwin, John E. Knox, Christopher A. Lipinski, Thomas H. Keller, Clifton E. Barry III and Cynthia S. Dowd


6.
N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum Pages 2263-2266 Strahil Berkov, Carles Codina, Francesc Viladomat and Jaume Bastida


7.
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates Pages 2267-2271 Alessio Innocenti, Andrea Scozzafava, Seppo Parkkila, Luca Puccetti, Giuseppina De Simone and Claudiu T. Supuran


8.
Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity Pages 2272-2276 Maria Laura Bolognesi, Federica Lizzi, Remo Perozzo, Reto Brun and Andrea Cavalli


9.
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound Pages 2277-2281 Cyrille Tomassi, Albert Nguyen Van Nhien, José Marco-Contelles, Jan Balzarini, Christophe Pannecouque, Erik De Clercq, Elena Soriano and Denis Postel


10.
Synthesis of 17β-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines Pages 2282-2287 Josée Provencher-Mandeville, Caroline Descôteaux, Sanat K. Mandal, Valérie Leblanc, Éric Asselin and Gervais Bérubé


11.
Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I Pages 2288-2291 Setsuya Sasho, Takashi Seishi, Mariko Kawamura, Ryo Hirose, Shinichiro Toki and Jun-ich Shimada


12.
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors Pages 2292-2295 Jinho Lee, Hwangeun Choi, Kyoung-Hee Kim, Shinwu Jeong, Jong-Wook Park, Chul-Su Baek and Sei-Hee Lee


13.
Chemically modified oligonucleotides with efficient RNase H response Pages 2296-2300 Birte Vester, Anne Marie Boel, Sune Lobedanz, B. Ravindra Babu, Michael Raunkjær, Dorthe Lindegaard, Raunak, Patrick J. Hrdlicka, Torben Højland, Pawan K. Sharma, Surender Kumar, Poul Nielsen and Jesper Wengel


14.
Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines Pages 2301-2305 Atma P. Dwivedi, Shailesh Kumar, Vandana Varshney, Amar B. Singh, Arvind K. Srivastava and Devi P. Sahu


15.
Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones Pages 2306-2310 Anna Aviñó, Isabel Navarro, Josep Farrera-Sinfreu, Miriam Royo, Juan Aymamí, Antonio Delgado, Amadeu Llebaria, Fernando Albericio and Ramon Eritja


16.
Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors Pages 2311-2315 Lisa A. Hasvold, Le Wang, Magdalena Przytulinska, Zhan Xiao, Zehan Chen, Wen-Zhen Gu, Philip J. Merta, John Xue, Peter Kovar, Haiying Zhang, Chang Park, Thomas J. Sowin, Saul H. Rosenberg and Nan-Horng Lin


17.
Deconstructing cytisine: The syntheses of (±)-cyfusine and (±)-cyclopropylcyfusine, fused ring analogs of cytisine Pages 2316-2319 Daniel Yohannes, Kristen Procko, Lorraine A. Lebel, Carol B. Fox and Brian T. O’Neill


18.
Increasing permeability of phospholipid bilayer membranes to alanine with synthetic α-aminophosphonate carriers Pages 2320-2323 Delia C. Danila, Xinyan Wang, Heather Hubble, Igor S. Antipin and Eugene Pinkhassik


19.
Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors Pages 2324-2328 Shenlin Huang, Zuosheng Liu, Shin-Shay Tian, Mark Sandberg, Tracy A. Spalding, Russell Romeo, Maya Iskandar, Zhiliang Wang, Donald Karanewsky and Yun He


20.
Synthesis and antibacterial activity of littorachalcone and related diphenyl ethers Pages 2329-2332 George A. Kraus, Ganesh Kumar, Gregory Phillips, Kris Michalson and Maria Mangano


21.
Meclonazepam analogues as potential new antihelmintic agents Pages 2333-2336 Aman Mahajan, Vipan Kumar, Nuha R.N. Mansour, Quentin Bickle and Kelly Chibale


22.
Synthesis of novel N-diazeniumdiolates based on hyperbranched polyethers Pages 2337-2341 Yuxia Kou and Ajun Wan


23.
Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens Pages 2342-2345 Govindasami Periyasami, Raghavachary Raghunathan, Gangadharan Surendiran and Narayanasamy Mathivanan


24.
Pharmacophore identification of Raf-1 kinase inhibitors Pages 2346-2350 Tian Zhu, Yu Jiao, Ya-Dong Chen, Xuan Wang, Hui-Fang Li, Lu-Yong Zhang and Tao Lu


25.
Synthesis of novel analogues of (+)-varitriol via olefin cross-metathesis reaction Pages 2351-2354 Lingaiah Nagarapu, Venkateswarlu Paparaju and Apuri Satyender


26.
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors Pages 2355-2361 Hui Huang, Daniel A. Hutta, Huaping Hu, Renee L. DesJarlais, Carsten Schubert, Ioanna P. Petrounia, Margery A. Chaikin, Carl L. Manthey and Mark R. Player


27.
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors Pages 2362-2367 Michael B. Wallace, Jun Feng, Zhiyuan Zhang, Robert J. Skene, Lihong Shi, Christopher L. Caster, Daniel B. Kassel, Rongda Xu and Stephen L. Gwaltney II


28.
TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs Pages 2368-2372 Ted L. Underiner, Bruce Ruggeri, Lisa Aimone, Mark Albom, Thelma Angeles, Hong Chang, Robert L. Hudkins, Kathryn Hunter, Kurt Josef, Candy Robinson, Linda Weinberg, Shi Yang and Allison Zulli


29.
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors Pages 2373-2376 Manas K. Haldar, Michael D. Scott, Nitesh Sule, D.K. Srivastava and Sanku Mallik


30.
Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents Pages 2377-2384 Myunji Park, Daniele Canzio and Thomas C. Bruice


31.
Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists Pages 2385-2389 Suk Youn Kang, Sung-Han Lee, Hee Jeong Seo, Myung Eun Jung, Kwangwoo Ahn, Jeongmin Kim and Jinhwa Lee


32.
Aryl–indolyl maleimides as inhibitors of CaMKIIδ. Part 1: SAR of the aryl region Pages 2390-2394 Daniel E. Levy, Dan-Xiong Wang, Qing Lu, Zheng Chen, John Perumattam, Yong-jin Xu, Albert Liclican, Jeffrey Higaki, Hanmin Dong, Maureen Laney, Babu Mavunkel and Sundeep Dugar


33.
Aryl-indolyl maleimides as inhibitors of CaMKIIδ. Part 2: SAR of the amine tether Pages 2395-2398 Daniel E. Levy, Dan-Xiong Wang, Qing Lu, Zheng Chen, John Perumattam, Yong-jin Xu, Jeffrey Higaki, Hanmin Dong, Albert Liclican, Maureen Laney, Babu Mavunkel and Sundeep Dugar


34.
Aryl–indolyl maleimides as inhibitors of CaMKIIδ. Part 3: Importance of the indole orientation Pages 2399-2403 Qing Lu, Zheng Chen, John Perumattam, Dan-Xiong Wang, Weiling Liang, Yong-jin Xu, Steven Do, Llorente Bonaga, Jeffrey Higaki, Hanmin Dong, Albert Liclican, Steve Sideris, Maureen Laney, Sundeep Dugar, Babu Mavunkel and Daniel E. Levy


35.
Pyrimidine-based inhibitors of CaMKIIδ Pages 2404-2408 Babu Mavunkel, Yong-jin Xu, Bindu Goyal, Don Lim, Qing Lu, Zheng Chen, Dan-Xiong Wang, Jeffrey Higaki, Indrani Chakraborty, Albert Liclican, Steve Sideris, Maureen Laney, Ulrike Delling, Rosanne Catalano, Linda S. Higgins, Hui Wang, Jing Wang, Ying Feng, Sundeep Dugar and Daniel E. Levy


36.
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors Pages 2409-2413 Scott D. Edmondson, Lan Wei, Jinyou Xu, Jackie Shang, Shiyao Xu, Jianmei Pang, Ashok Chaudhary, Dennis C. Dean, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Reshma A. Patel, Sangita B. Patel, Giovanna Scapin, Joseph K. Wu, Maria G. Beconi, Nancy A. Thornberry and Ann E. Weber


37.
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3 Pages 2414-2419 Martin E. Hayes, Eric C. Breinlinger, Grier A. Wallace, Pintipa Grongsaard, Wenyan Miao, Michael J. McPherson, Robert H. Stoffel, David W. Green and Gregory P. Roth


38.
Synthesis and study of antiviral and anti-radical properties of aminophenol derivatives Pages 2420-2423 O. Shadyro, G. Ksendzova, G. Polozov, V. Sorokin, E. Boreko, O. Savinova, B. Dubovik and N. Bizunok


39.
Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine–bombesin conjugate Pages 2424-2427 Céléna Dubuc, Réjean Langlois, François Bénard, Nicole Cauchon, Klaus Klarskov, Paul Tone and Johan E. van Lier


40.
Sulfonamidolactam inhibitors of coagulation factor Xa Pages 2428-2433 Joanne M. Smallheer, Shuaige Wang, Mia L. Laws, Suanne Nakajima, Zilun Hu, Wei Han, Irina Jacobson, Joseph M. Luettgen, Karen A. Rossi, Alan R. Rendina, Robert M. Knabb, Ruth R. Wexler, Patrick Y.S. Lam and Mimi L. Quan


41.
Solid-phase synthesis of new pyrrolobenzodiazepine–chalcone conjugates: DNA-binding affinity and anticancer activity Pages 2434-2439 Ahmed Kamal, N. Shankaraiah, S. Prabhakar, Ch. Ratna Reddy, N. Markandeya, K. Laxma Reddy and V. Devaiah


42.
Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones Pages 2440-2444 Josep Farrera-Sinfreu, Anna Aviñó, Isabel Navarro, Juan Aymamí, Natàlia G. Beteta, Sònia Varón, Ricardo Pérez-Tomás, Wilmar Castillo-Avila, Ramon Eritja, Fernando Albericio and Miriam Royo


43.
Glycosyl and polyalcoholic prodrugs of lonidamine Pages 2445-2450 G. Giorgioni, S. Ruggieri, A. Di Stefano, P. Sozio, B. Cinque, L. Di Marzio, G. Santoni and F. Claudi


44.
Xylose as a carrier for boron containing compounds Pages 2451-2454 Mårten Jacobsson, Cecilia Winander, Katrin Mani and Ulf Ellervik


45.
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles Pages 2455-2458 Caroline M. Reid, Charles Ebikeme, Michael P. Barrett, Eva-Maria Patzewitz, Sylke Müller, David J. Robins and Andrew Sutherland


46.
Fluorination of triptolide and its analogues and their cytotoxicity Pages 2459-2463 Yutaka Aoyagi, Yukio Hitotsuyanagi, Tomoyo Hasuda, Saki Matsuyama, Haruhiko Fukaya, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki and Shusuke Hashimoto


47.
Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation Pages 2464-2466 Etsuo Niki, Akiko Fukuhara, Yo Omata, Yoshiro Saito and Yasukazu Yoshida


48.
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine Pages 2467-2470 Brandon D. Gaddis, Charles M. Rubert Pérez and Jean Chmielewski


49.
Renin inhibition activity by chitooligosaccharides Pages 2471-2474 Pyo-Jam Park, Chang-Bum Ahn, You-Jin Jeon and Jae-Young Je


50.
1-Aryl-tetrahydroisoquinoline analogs as active anti-HIV agents in vitro Pages 2475-2478 Pi Cheng, Ning Huang, Zhi-Yong Jiang, Quan Zhang, Yong-Tang Zheng, Ji-Jun Chen, Xue-Mei Zhang and Yun-Bao Ma


51.
Docking-based 3D-QSAR study for 11β-HSD1 inhibitors Pages 2479-2490 Jin Hee Lee, Nam Sook Kang and Sung-Eun Yoo


52.
β-Lactam congeners of orlistat as inhibitors of fatty acid synthase Pages 2491-2494 Wei Zhang, Robyn D. Richardson, Supakarn Chamni, Jeffrey W. Smith and Daniel Romo


53.
Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90) Pages 2495-2498 Christine Radanyi, Gaëlle Le Bras, Samir Messaoudi, Céline Bouclier, Jean-François Peyrat, Jean-Daniel Brion, Véronique Marsaud, Jack-Michel Renoir and Mouâd Alami


54.
Sugar Chips immobilized with synthetic sulfated disaccharides of heparin/heparan sulfate partial structure Pages 2499-2504 Masahiro Wakao, Akihiro Saito, Koh Ohishi, Yuko Kishimoto, Tomoaki Nishimura, Michael Sobel and Yasuo Suda


55.
A novel cholic acid-based contrast enhancement agent for targeted MRI Pages 2505-2508 Hyun-Soon Chong, Hyun A. Song, Sooyoun Lim, Keith Macrenaris, Xiang Ma, Haisung Lee, Phuong Bui and Thomas Meade


56.
Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors Pages 2509-2512 Geraldine C. Harriman, Matthias Brewer, Robert Bennett, Cyrille Kuhn, Marc Bazin, Greg Larosa, Paul Skerker, Nancy Cochran, Debra Gallant, Deborah Baxter, Dominic Picarella, Bruce Jaffee, Jay R. Luly and Michael J. Briskin